Abstract
In the last 2 years, two newborns were found to have persistent hypoglycaemia due to nesidioblastosis. Both required more than 15 mg/kg/min IV glucose and had inappropriately high plasma insulin levels. Near-total pancreatectomy (NTP) with splenic conservation was curative in both, with negligible morbidity and no mortality. Prompt diagnosis and stringent control of plasma glucose with hourly monitoring in an intensive care unit, use of a central venous line, and oral diazoxide prevented subsequent neurological handicaps. A high index of suspicion for this rare disorder should be kept in mind in a chubby infant who is jittery, apathetic, and has seizures with hypoglycaemia. Medical management is required to confirm the nonketotic, hyperinsulinaemic hypoglycaemia, whereas NTP provides a long-term cure.
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Rohatgi, M., Gupta, D.K., Menon, P.S.N. et al. Nesidioblastosis in infants: report of two cases and review of the literature. Pediatr Surg Int 6, 365–367 (1991). https://doi.org/10.1007/BF00178659
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DOI: https://doi.org/10.1007/BF00178659