Abstract
Neuroma formation at the proximal stump following nerve severance is a common problem in peripheral nerve surgery. To prevent its formation, it is suggested that an epineural barrier is an effective and physiologic method when compared to other techniques. In this study, the right sciatic nerves of 30 rats were severed and their proximal stumps were covered by epineural flaps and free epineural grafts. All rats were explored three months later and morphologic and histopathologic evaluation of the proximal stump was made to estimate the amount of neuroma formation. It was concluded that free epineural grafting technique was the most effective method of preventing the process.
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References
Battista AF, Cravioto H (1981) Neuroma formation and prevention by fascicle ligation in the rat. Neurosurgery 8: 191–204
Dellon AL, Mackinnon SE (1986) Treatment of painful neuroma by neuroma resection and muscle implantation. Plast Reconstr Surg 77:427–436
Goldstein TA, Sturim HS (1985) Intraosseous nerve transposition for treatment of painful neuromas. J Hand Surg 10A: 270–274
Gutmann L, Medawar PB (1942) The chemical inhibition of fiber regeneration and neuroma formation in peripheral nerves. J Neurol Neurosurg Psychiatry 5:130
Kon M, Bloem JJA, M (1987) The treatment of amputation neuromas in fingers with a centrocentral nerve union. Ann Plast Surg 18:506–510
Mann RA, Reynolds JC (1983) Interdigital neuroma-a critical clinical analysis. Foot Ankle 3:238
Martini A, Fromm B (1989) A new operation for the prevention and treatment of amputation neuromas. J Bone Joint Surg [Br] 71:379–82
Muehleman C, Rahimi F (1990) Effectiveness of an epineural barrier in reducing axonal regeneration and neuroma formation in the rat. J Foot Surg 29:260–264
Petropoulos PC, Stefanko S (1961) Experimental studies of posttraumatic neuromas under various physiologic conditions. J Surg Res 1:235–2240
Robbins TH (1986) Nerve capping in the treatment of troublesome terminal neuromata. Br J Plast Surg 39:239
Sunderland S (1965) The connective tissues of peripheral nerves. Brain 88:841
Sunderland S (1968) Nerves and nerve injuries. Williams & Wilkins, Baltimore
Sunderland S (1978) Nerves and nerve injuries, 2nd edn. Churchill Livingstone, Edinburgh
Swanson AB, Boeve NR, Lumsden RM (1977) The prevention and treatment of amputation neuromata by silicone capping. J Hand Surg 2:70–78
Tripper JW, Booth PM (1976) Treatment of painful neuroma of sensory nerves in the hand: a comparison of traditional and newer methods. J Hand Surg 1:144
Tupper JW (1980) Fascicular nerve repair. In: Jewett DL, McCarrol HR Jr (eds). Nerve repair and regeneration: its clinical and experimental basis. Mosby, St Louis, p 320
Williams HB (1984) The painful stump neuroma and its treatment. Clin Plast Surg 11:79
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Durak, N., Yüksel, F. & Kislaoglu, E. Effectiveness of epineural barriers as a flap and free graft in reducing neuroma formation in the rat following sciatic nerve severance. Eur J Plast Surg 18, 272–275 (1995). https://doi.org/10.1007/BF00178538
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DOI: https://doi.org/10.1007/BF00178538