Abstract
Two patients with recurrent medulloblastomas were treated with combined oral and intra-venous chemotherapy followed by intra-arterial BCNU. The 7 days course of oral and intra-venous chemotherapy consisted of CCNU and Procarbazin orally and Vincristine intra-venously (PCV), repeated after 6 weeks. Intra-arterial chemotherapy consisted of 4 cycles of BCNU. Both patients responded well to treatment, evaluated by CT scans. One of the patients died of a new local recurrence 6 months after initiation of chemotherapy, whereas the other patient remains well, without CT evidence of tumour 36 months after the start of the treatment. No serious adverse side-effects related to the treatment were seen.
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Watne, K., Hager, B. & Hirschberg, H. Intra-arterial BCNU in the treatment of recurrent medulloblastoma. J Neuro-Oncol 8, 139–143 (1990). https://doi.org/10.1007/BF00177836
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DOI: https://doi.org/10.1007/BF00177836