Abstract
•Background: In previous studies Doppler sonography was proven to the useful for diagnostics and follow-up of malignant melanomas of the choroid.
•Methods: To evaluate the correlation between Doppler sonographical findings and the histological tumor vascularization, we examined five eyes of five patients with malignant melanoma of the choroid before enucleation with an ATL Ultramark-8 Duplex scanner and compared these results with computerized planimetry of histological tumor vascularization after immunohistochemical staining of vascular endothelium with anti-factor-VIII antibodies.
•Results: We found no definite correlation of flow velocities with histological parameters of tumor vascularization. The tendency was for a decrease in maximum flow velocities as histological vascularization increased.
•Conclusions: Due to (1) the usual lack of sensitivity parameters of the used Duplex device for the clinical user and (2) the unpredictable branching pattern within a melanoma resulting in an unknown angle of incidence of the Doppler beam, we conclude that the quantitative results of Doppler sonography require cautious interpretation. Nevertheless, presence or absence of Doppler shifts is a valuable parameter for the follow-up of irradiated tumors.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Berger RW, Guthoff R, Helmke K, Winkler P (1990) Doppler ultrasonography in the follow-up malignant melanoma of the choroid. Ultrasonogr Ophthalmol 12:327–331
Guthoff R, Berger RW, Helmke K, Winckler B (1989) Dopplersonographische Befunde bei intraokularen Tumoren. Fortschr Ophthalmol 86:239–241
Guthoff RF, Berger RW, Winkler P, Helmke K, Chumbley LC (1991) Doppler ultrasonography of the ophthahnic and central retinal vessels. Arch Ophthalmol 109:532–536
Guthoff R, Berger R, Winkler P, Helmke K, Chumbley LC (1991) Doppler ultrasonography of malignant melanoma of the choroid. Arch Ophthalmol 109:537–541
Lieb WE, Cohen SM, Shields JA, Mitchell DG (1990) Darstellung von intraokularen und orbitalen Gefäßen mittels Angiodynographie. Fortschr Ophthalmol 87:537–539
Lieb WE, Shields JA, Cohen SM, Merton DA, Mitchell DG, Shields CL, Goldberg BB (1990) Color Doppler imaging in the management of intraocular tumors. Ophthalmology 97:1660–1664
Sehested M, Hou-Jensen K (1982) Factor VIII-related antigen as an endothelial cell marker in benign and malignant diseases. Virchows Arch 391:217–225
Srivastava A, Hughes LE, Woodcock JP, Laidler P (1989) Vascularity in cutaneous melanoma detected by Doppler sonography and histology: correlation with tumor behavior. Br J Cancer 59:89–91
Wolff-Kormann PG, Kormann BA, Spengel FA, Hasenfratz GC, Riedel KG (1991) Duplex-Sonographie in der Ophthalmologie: aktuelle Forschungsansätze und Perspektiven. Bildgebung 58:71–75
Wolff-Kormann PG, Kormann BA, Riedel KG, Hasenfratz GC, Stefani FH, Spengel FA, Lund OE (1992) Quantitative color doppler imaging in untreated and irradiated choroidal melanomas. Invest Ophthalmol 33:1928–1933
Wolff-Kormann PG, Kormann BA, Riedel KG, Hasenfratz GC, Spengel FA (1992) Quantitative Duplex and color Doppler ultrasound in the follow-up of ß-irradiated (106Ru/106Rh) choroidal melanomas. German J Ophthalmol 1:151–155
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Damms, T., Winter, R., Schäfer, H. et al. Correlation of histological tumor vascularization and Doppler sonography in patients with malignant melanoma of the choroid. Graefe's Arch Clin Exp Ophthalmol 233, 257–260 (1995). https://doi.org/10.1007/BF00177646
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00177646