Abstract
This study evaluated the effects of steroid inhalation on the deposition pattern of Tc-99m human serum albumin (Tc-99m HSA) radioaerosols in 25 asthma patients. A total of 12 normal controls also underwent the same examination. The pattern of radioaerosol deposition was quantitatively evaluated as the percentage of total deposition (PTD) in the central, intermediate, and peripheral regions of the right lung. The baseline PTD was calculated before and after the administration of a 1-week course of inhalation therapy of 0.05 mg beclomethasone dipropionate four times daily. There were significant differences in PTD between normal controls and asthma patients. Significant differences were also found before and after corticosteroid inhalation therapy in asthma patients. In conclusion, a week-long course of beclomethasone dipropionate inhalation therapy does influence the deposition patterns of aerosols in asthma patients, based on the findings of Tc-99m HSA radioaerosol inhalation lung scintigraphy.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
ATS Committee on Diagnostic Standards for Nontuberculous Respiratory Diseases (1962) Chronic bronchitis, asthma and pulmonary emphysema. Arch Environ Health 5:375–382
Boushey HA, Holtzman MJ, Sheller JR, Nadel JA (1980) Bronchial hyperreactivity. Am Rev Respir Dis 121:389–413
Boushey HA, Holtzman MJ (1985) Experimental airway inflammation and hyperreactivity. Am Rev Respir Dis 131:312–313
Brompton Hospital/MRC collaborative trial (1974) Double-blind trial comparing two dose schedules of beclomethasone dipropionate in the treatment of bronchial asthma. Lancet 2: 303–307
Easton JG (1981) Effect of an inhaled corticosteroid on methacholine airway reactivity. J Allergy Clin Immunol 67:388–390
Falliers CJ, Chai H, Molk L, Bane H, Cardoso RR (1972) Pulmonary and adrenal effects of alternate day corticosteroid therapy. J Allergy Clin Immunol 49:156–166
Godfrey S, Balfour-Lynn L, Rooley M (1978) A three to five year follow-up of the use of the aerosol steroid, beclomethasone dipropionate, in childhood asthma. J Allergy Clin Immunol 62:335–339
Juniper EF, Frith PA, Hargreave FE (1982) Long-term stability of brochlial responsiveness to histamine. Thorax 37:288–291
Kraan J, Koeter HG, Mark TW, Van de Mark TW, Sluiter HJ, De Vries K (1985) Changes in bronchial hyperreactivity induced by 4 weeks treatment with anti asthmatic drugs in patients with allergic asthma: comparison between budesonide and terbutaline. J Allergy Clin Immunol 76:628–636
Laitinen LA, Heino M, Laitine A, Kava T, Haahtela T (1985) Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis 131:599–606
McFadden ER Jr (1984) Pathogenesis of asthma. J Allergy Clin Immunol 73:413–424
Persson CGA (1986) Role of plasma exudation in asthmatic airways. Lancet 2:1126–1128
Pircher FJ, Temple JR, Kirsch WT (1965) Distribution of pulmonary ventilation determined by radioisotope scanning. AIR Am J Roentgenol 94:807–814
Taplin GV, Poe ND, Greenberg A (1966) Lung scanning following radioaerosol inhalation. J Nucl Med 7:77–87
Wiggs B, Moreno R, James A, Hogg JC, Pare P (1991) A model of the mechanics of airway narrowing in asthma. In: Kaliner MA, Barnes PJ, Persson CGA (eds) Asthma: Its Pathology and Treatment. Marcel Dekker, Inc., New York, pp 73–101
Author information
Authors and Affiliations
Additional information
Offprint requests to: C.-H. Kao
Rights and permissions
About this article
Cite this article
Kao, C.H., Lin, H.T., Yu, S.L. et al. Effects of corticosteroid inhalation therapy on the deposition pattern of Tc-99m human serum albumin radioaerosols in asthma. Lung 173, 291–296 (1995). https://doi.org/10.1007/BF00176892
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00176892