Abstract
Electrophysiological methods were applied to 160 healthy adult male guinea pigs in order to investigate the effects of pure-tone exposure for 24 h on the inner ear. A reduction in cochlear microphonics (CM), action potential (AP) and endocochlear potential was observed following exposure to 110 dB at 100 Hz, 100 dB at 200 and 600 Hz and 95 dB at 2 kHz. The observed K+ endolymphatic concentration during 40 min anoxia remained unchanged. In contrast K+ decreased in control animals and following exposure to pure tones varying from 110 dB at 60 Hz to 85 dB at 2 kHz. These findings indicate that high frequency tones have a greater effect on inner ear functions than those of lower frequency, decreasing the maximum output voltage of CM and AP but not changing K+ endolymphatic concentration.
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References
Abe N, Ohyama S, Shida T (1981) Method of fabrication of double barrel K+ ion electrode and its application to the physiology of cochlea (in Japanese). Audiology 2:397–398
Avinash GB, Nuttall AL, Raphael Y (1993) 3-D analysis of Faction in stereocilia of cochlear hair cell after loud noise exposure. Hear Res 67:139–146
Coulee W, Benett J, Margaret L (1993) Turn-specific differences in the endocochlear potential between albino and pigmented guinea pigs. Hear Res 65: 141–150
Fujii M (1970) The experimental study of acoustic trauma on peripheral hearing organ (in Japanese). Pract Otol 63: 557–608
Fujita T, Sugisawa T, Matsui T, Takahashi M, Inada N, Ishida A, Yamamura K (1991) Effect of 250 and 500 Hz exposure on the inner ear of guinea pigs as determined by electrophysiological techniques. ORL 53:147–152
Gao W, Ding D, Aheng X, Ruan F, Liu Y (1992) A comparison of changes in the stereocilia between temporary and permanent hearing losses in acoustic trauma. Hear Res 62:27–41
Ikeda K, Morizono T (1989) Electrochemical profiles for monovalent ions in the stria vascularis: cellular model of ion transport mechanism. Hear Res 39: 279–286
Konishi T, Salt AN (1980) Permeability to potassium of the endolymph barrier and its possible relation to hair cell function. Exp Brain Res 40:457–463
Konishi T, Salt AN (1983) Electrochemical profiles for potassium ion across the cochlear hair cell membranes of guinea pigs. Hear Res 11: 219–233
Kryter KD (1985) Noise-induced hearing loss and its prediction. In: Kryter KD (ed) The effect of noise on man, 2nd edn. Academic Press, New York, pp 220
Legouix JP, Persan A (1974) Investigation of the source of whole-nerve action potential. J Acoust Soc Am 56:1222–1225
Lewis GT, Saunders JC, Egelman E, Derosier (1982) Changes in the organization of action filaments in the stereocilia of noise-damaged lizard cochlea. Hear Res 7:181–197
Lim DJ (1980) Cochlea anatomy related to cochlear microphonics; a review. J Acoust Soc Am 67:1686–1695
Mori H, Konishi T (1985) Permeability to chloride ions of the cochlea partition in normal guinea pigs. Hear Res 17:227–236
Muratsuka Y, Ueda H, Konishi T (1989) Effects of sodium bromate on ionic concentrations and osmolalities of the cochlear fluids in guinea pigs. Hear Res 39:241–250
Oftner FF, Dallos P, Cheatham MA (1987) Positive endocochlear potential: mechanism of production by marginal cells of stria vascularis. Hear Res 29: 117–124
Pickles JO, Comis SD, Osborne MP (1984) Cross-lines between stereocilia in the guinea pig organ Corti and their possible relation to sensory transduction. Hear Res 15: 103–112
Sugisawa T, Nemoto R, Inada N, Ishida A, Yamamura K (1994) Effect of 4 kHz tone exposure on the guinea pig inner ear: relation in the change of cochlear microphonics, action potential, electrochemical potential and K+ ion concentration induced by noise exposure. ORL 56:263–268
Sugisawa T, Ishida A, Hotta S, Yamamura K (1994) The effect of 6 kHz tone exposure on inner ear function of the guinea pig: relation to changes in cochlear microphonics, action potential, endocochlear potential and chemical potential of K+ ions, using a double-barrel glass electrode. Eur Arch Otorhinolaryngol 251:154–159
Yamamura K, Sugisawa T, Inada N, Matsui T, Ishida A (1992) Study of the effect of 350 Hz tone exposure on electrophysiological function of the inner ear of guinea pigs. ORL 54:10–14
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Hotta, S., Sugisawa, T., Rob, T. et al. A comparative study on the effect of pure-tone exposure of the guinea pig cochlea. Eur Arch Otorhinolaryngol 253, 45–51 (1996). https://doi.org/10.1007/BF00176703
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DOI: https://doi.org/10.1007/BF00176703