Abstract
Iodine-131 labelled metaiodobenzylguanidine ([131I]MIBG) has a diagnostic and therapeutic role in the management of neural crest tumours, particularly neuroblastoma, malignant phaeochromocytoma and paraganglioma. With therapeutic amounts of [131I]MIBG it is essential that the amount of free [131I]iodide, the most important impurity, is known. In clinical practice the percentage of free [131I]iodide seen in a [1311]MIBG infusion concentrate increased from 2.2%±0.67% to 3.6%±0.39% (mean ± SD; n=23) 1 day after production. At the time of use the percentage of free [131I]iodide was always below our upper limit of acceptance of 5%. Since 5% of free [131I]iodide is within practical reach in our environment, a higher percentage at the time of pre-administration quality control is not accepted in the Netherlands Cancer Institute.
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Correspondence to: A.R. Wafelman
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Wafelman, A.R., Suchi, R., Hoefnagel, C.A. et al. Radiochemical purity of iodine-131 labelled metaiodobenzylguanidine infusion fluids: a report from clinical practice. Eur J Nucl Med 20, 614–616 (1993). https://doi.org/10.1007/BF00176557
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DOI: https://doi.org/10.1007/BF00176557