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Retinal pigment epithelium implantation in the rabbit: technique and morphology

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Abstract

Dysfunction of the retinal pigment epithelium (RPE) is a major component of many degenerative disorders of the retina. We have developed a modified pars plana technique for subretinal implantation of homologous, cultured, carbon-loaded RPE cells in the rabbit. The natural history and morphologic behavior of the implanted RPE cells for up to 6 weeks after transplantation were observed in successful procedures.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Southern California School of Medicine, and the Doheny Eye Institute, 1355 San Pablo Street, 90033, Los Angeles, CA, USA

    Amal A. El Dirini, Hsin-min Wang, Thomas E. Ogden & Stephen J. Ryan

Authors
  1. Amal A. El Dirini
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  2. Hsin-min Wang
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  3. Thomas E. Ogden
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  4. Stephen J. Ryan
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Additional information

Supported in part by NIH grants EY-01545 and EY-03040, the latter a Core Grant for Vision Research

Offprint requests to: S. Ryan

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El Dirini, A.A., Wang, Hm., Ogden, T.E. et al. Retinal pigment epithelium implantation in the rabbit: technique and morphology. Graefe's Arch Clin Exp Ophthalmol 230, 292–300 (1992). https://doi.org/10.1007/BF00176307

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  • DOI: https://doi.org/10.1007/BF00176307

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