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Detection of rhinorrhoea by cisternography in combination with single photon emission tomography, following lumbar injection of iodine-123-labelled albumin

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Abstract

Eight patients were examined. Seven had verified rhinorrhoea and six had had one or more episodes of pneumococcal meningitis. In four of the patients a fistula could not be visualized by computed tomography. All eight patients had injections of iodine-123-labelled albumin by lumbar puncture. Tomoscintigraphy (SPET) was performed 3, 6 and 8–9 h after injection. After 6–8 h we were able to demonstrate a fistula in seven of the patients with verified rhinorrhoea and the findings were confirmed by a subsequent operation. In one of the patients we were not able to visualize any leak of cerebrospinal fluid into the nasal cavity. This patient was not operated upon and we were not able to verify the findings in this patient. The operated patients all did well after the operation with no relapse of meningitis. In conclusion, SPECT-cisternography after intralumbar injection of iodine-123-labelled albumin is a valuable diagnostic tool for the detection of small fistulae in patients with rhinorrhoea.

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References

  • Crow HJ, Koegh C, Northfield DWC (1956) The localization of cerebrospinal fluid fistulae. Lancet 271:325–327

    Google Scholar 

  • Front D, Penning L (1971) Occult spontaneous cerebrospinal fluid rhinorrhoea diagnosed by isotope cisternography. Neuroradiology 2:167–169

    Google Scholar 

  • Greenwood FC, Hunter WM, Glover JS (1963) The preparation of 131I-labelled human growth hormone of high specific radioactivity. Biochem J 89:114–123

    Google Scholar 

  • Jefferey P, Sostre S, Scherer LR, Kasecamp W, Camargo EE (1990) Bowel visualization during indium-111-labelled diethylene triamine pentaacetic acid cisternography due to massive cerebrospinal fluid leak. Eur J Nucl Med 17:365–368

    Google Scholar 

  • Lemke TH, Beeger R (1980) Preoperative klinische, radiologische und nuklearmedizinische Diagnostik und intraoperativer Befund bei frontobasaler Liquorfistel. Laryngol Rhinol 59:797–803

    Google Scholar 

  • Mamo L, Cophignon J, Rey A, Thurel C (1982) A new radionuclide method for the diagnosis of posttraumatic cerebrospinal fistulas. J Neurosurg 57:92–98

    Google Scholar 

  • McKusick KA, Malmud LS, Kordela PA, Wagner HN (1973) Radionuclide cisternography: normal values of nasal secretion of intrathecally injected 111In-DTPA. J Nucl Med 14:933–934

    Google Scholar 

  • Meada T, Ishida H, Matsuda H, Yokoyama K, Seki H, Tonami N, Hisada K (1984) The utility of radionuclide myelography and cisternography in the progress of cerebrospinal fluid leaks. Eur J Nucl Med 9:416–418

    Google Scholar 

  • Mundiger F, Bühler J (1979) Die Diagnose der Rhinoliquorrhoe mit dem 131J-Hippuran-Tupfertest. Nucl Med 18:91–97

    Google Scholar 

  • Oberson R (1972) Radioisotopic diagnosis of rhinorrhoea. Radiol Clin Biol 41:28–35

    Google Scholar 

  • Otto H, Bock WJ, Poll W, Sauer J, Strötges MW (1973) Die Leistungsfähigkeit der Szintigraphie bei der Diagnostik von Liquorfisteln. Fortschr Röntgenstr 118:641–648

    Google Scholar 

  • Otto H-J, Koch RD (1980) Indikation und Aussagewert der Szintigraphie der intrakraniellen Liquorräume. Psychiatr Neurol Med Psychol 32:658–662

    Google Scholar 

  • Schicha H, Schürnbrand P, Schaake T, Emrich D (1983) Zur Problematik des Nachweises einer Rhinoliquorrhoe mit 99mTc-markiertem Humanserumalbumin. Nucl Med 22:106–114

    Google Scholar 

  • Schicha H, Voth E, Emrich D (1985) Detection of occult and intermittent rhinorrhoea using 111In-DTPA. Eur J Nucl Med 11:76–79

    Google Scholar 

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Nielsen, J.T., Andersen, K., Nielsen, B.V. et al. Detection of rhinorrhoea by cisternography in combination with single photon emission tomography, following lumbar injection of iodine-123-labelled albumin. Eur J Nucl Med 19, 966–970 (1992). https://doi.org/10.1007/BF00175864

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  • DOI: https://doi.org/10.1007/BF00175864

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