Summary
Neurokinin A, neurokinin B and substance P caused concentration-related contractions of rabbit isolated aorta with pD2 values of 8.1, 6.9 and 6.0, respectively. [D-Pro2, D-Trp7,9]-substance P, a competitive tachykinin antagonist, had pA2 values of 5.3 against neurokinin A, 5.1 against neurokinin B and 5.2 against substance P indicating that tachykinin receptors mediated responses to the agonists. [pGIu5,MePhe8,-McGly9]-substance P 5–11 (DiMe-C7), senktide and septide did not contract the aorta. It is concluded that of the known tachykinin receptors smooth muscle of the rabbit isolated aorta contains only the NK-2 type.
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Constantine, J.W., Lebel, W.S. & Woody, H.A. Smooth muscle of rabbit isolated aorta contains the NK-2 tachykinin receptor. Naunyn-Schmiedeberg's Arch Pharmacol 342, 722–724 (1990). https://doi.org/10.1007/BF00175719
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DOI: https://doi.org/10.1007/BF00175719