Abstract
The bidomain model, which describes the behavior of many electrically active tissues, is equivalent to a multi-dimensional cable model and can be represented by a network of resistors and capacitors. For a two-dimensional sheet of tissue, the intracellular and extracellular conductivity tensors can be visualized as two ellipses. For any pair of conductivity tensors, a coordinate transformation can be found that reduces the extracellular ellipse to a circle and aligns the intracellular ellipse with the coordinate axes. The eccentricity of the intracellular ellipse in this new coordinate system is an important parameter. It can have two special values: zero (in which case the tissue has equal anisotropy ratios) or one (in which case the tissue is comprised of one-dimensional fibers coupled through the two-dimensional extracellular space). Thus the bidomain model provides a unifying framework within which the electrical behavior of a wide variety of nerve and muscle tissues can be studied.
When the anisotropy ratios in the intracellular and extracellular domains are not equal, stimulation with an anode always causes depolarization of some region of tissue. An analogous effect occurs in models that describe one-dimensional fibers, in which an “activating function” determines the site of stimulation. Experiments indicate that cardiac muscle does not have equal anisotropy ratios. Therefore, models developed to describe stimulation of axons may also help in understanding stimulation of two- or three-dimensional cardiac tissue, and may explain the concept of anodal stimulation of cardiac tissue through a “virtual cathode”.
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References
Altman, K. W., Plonsey, R.: Development of a model for point source electrical fibre bundle stimulation. Med. Biol. Eng. Comput. 26, 466–475 (1988)
Altman, K. W., Plonsey, R.: Point source nerve bundle stimulation: Effects of fiber diameter and depth on simulated excitation. IEEE Trans. Biomed. Eng. 37, 688–698 (1990)
Aravind, P. K.: Geometrical interpretation of the simultaneous diagonalization of two quadratic forms. Am. J. Phys. 57, 309–311 (1989)
Barr, R. C., Plonsey, R.: Propagation of excitation in idealized anisotropic two-dimensional tissue. Biophys. J. 45, 1191–1202 (1984)
Clerc, L.: Directional differences of impulse spread in trabecular muscle from mammalian heart. J. Physiol. 255, 335–346 (1976)
Colli Franzone, P., Guerri, L., Rovida, S.: Wavefront propagation in an activation model of the anisotropic cardiac tissue: Asymptotic analysis and numerical simulations. J. Math. Biol. 28, 121–176 (1990)
Colli Franzone, P., Guerri, L., Tentoni, S.: Mathematical modeling of the excitation process in myocardial tissue: Influence of fiber rotation on wavefront propagation and potential field. Math. Biosci. 101, 155–235 (1990)
Dekker, E.: Direct current make and break thresholds for pacemaker electrodes on the canine ventricle. Circ. Res. 27, 811–823 (1970)
Eisenberg, R. S., Barcilon, V., Mathias, R. T.: Electrical properties of spherical syncytia. Biophys. J. 48, 449–460 (1979)
Geselowitz, D. B., Miller, W. T., III: A bidomain model for anisotropic cardiac muscle. Ann. Biomed. Eng. 11, 191–206 (1982)
Geselowitz, D. B., Barr, R. C., Spach, M. S., Miller, W. T., III: The impact of adjacent isotropic fluids on electrograms from anisotropic cardiac muscle. A modeling study. Circ. Res. 51, 602–613 (1982)
Goldstein, H.: Classical Mechanics. Reading, Mass.: Addison-Wesley 1981
Goto, M., Brooks, C. McC.: Membrane excitability of the frog ventricle examined by long pulses. Am. J. Physiol. 217, 1236–1245 (1969)
Henriquez, C. S., Plonsey, R.: Effect of resistive discontinuities on waveshape and velocity in a single cardiac fibre. Med. Biol. Eng. Comput. 25, 428–438 (1987)
Henriquez, C. S., Plonsey, R.: Simulation of propagation along a cylindrical bundle of cardiac tissue — I: Mathematical formulation. IEEE Trans. Biomed. Eng. 37, 850–860 (1990)
Henriquez, C. S., Plonsey, R.: Simulation of propagation along a cylindrical bundle of cardiac tissue — II: Results of Simulation. IEEE Trans. Biomed. Eng. 37, 861–875 (1990)
Henriquez, C. S., Trayanova, N., Plonsey, R.: Potential and current distributions in a cylindrical bundle of cardiac tissue. Biophys. J. 53, 907–918 (1988)
Henriquez, C. S., Trayanova, N., Plonsey, R.: A planar slab model for cardiac tissue. Ann. Biomed. Eng. 18, 367–376 (1990)
Hoshi, T., Matsuda, K.: Excitability cycle of cardiac muscle examined by intracellular stimulation. Jpn. J. Physiol. 12, 433–446 (1962)
Jack, J. J. B., Noble, D., Tsien, R. W.: Electric Current Flow in Excitable Cells. Oxford, UK: Clarendon Press 1975
Keener, J. P.: On the formation of circulating patterns of excitation in anisotropic excitable media. J. Math. Biol. 26, 41–56 (1988)
Krassowska, W., Pilkington, T. C., Ideker, R. E.: The closed form solution to the periodic core-conductor model using asymptotic analysis. IEEE Trans. Biomed. Eng. 34, 519–531 (1987)
Krassowska, W., Pilkington, T. C., Ideker, R. E.: Periodic conductivity as a mechanism for cardiac stimulation and defibrillation. IEEE Trans. Biomed. Eng. 34, 555–560 (1987)
Krassowska, W., Pilkington, T. C., Ideker, R. E.: Modelling the periodicity of cardiac muscle. J. Electrocardiol. 22 (Suppl), 41–47 (1989)
Krassowska, W., Pilkington, T. C., Ideker, R. E.: Potential distribution in three-dimensional periodic myocardiuim — Part I: Solution with two-scale asymptotic analysis. IEEE Trans. Biomed. Eng. 37, 252–266 (1990)
Krassowska, W., Pilkington, T. C., Ideker, R. E.: Potential distribution in three-dimensional periodic myocardium — Part II: Application to extracellular stimulation. IEEE Trans. Biomed. Eng. 37, 267–284 (1990)
Krassowska, W., Knisley, S. B., Pilkington, T. C., Ideker, R. E.: Modeling high-frequency pacing with a discrete cardiac strand. Proc. Annu. Conf. IEEE Eng. Med. Biol. Soc. 12, 624–625 (1990)
Landau, L., Lifshitz, E.: Electrodynamics of Continuous Media. New York: Pergamon Press 1960
Leon, L. J., Horacek, B. M.: Computer model of excitation and recovery in the anisotropic myocardium. I. Rectangular and cubic arrays of excitable elements. J. Electrocardiol. 24, 1–15 (1991)
Leon, L. J., Horacek, B. M.: Computer model of excitation and recovery in the anisotropic myocardium. II. Excitation in the simplified left ventricle. J. Electrocardiol. 24, 17–31 (1991)
Leon, L. J., Horacek, B. M.: Computer model of excitation and recovery in the anisotropic myocardium. III. Arrhythmogenic conditions in the simplified left ventricle. J. Electrocardiol. 24, 33–41 (1991)
Mathias, R. T.: Steady-state voltages, ion fluxes, and volume regulation in syncytial tissues. Biophys. J. 48, 435–448 (1985)
Miller, W. T. III, Geselowtiz, D. B.: Simulation studies of the electrocardiogram, I. The normal heart. Circ. Res. 43, 301–315 (1978)
Muler, A. L., Markin, V. S.: Electrical properties of anisotropic nerve-muscle syncytia — I. Distribution of the electrotronic potential. Biofizika 22, 307–312 (1977)
Muler, A. L., Markin, V. S.: Electrical properties of anisotropic nerve-muscle syncytia — II. Spread of flat front of excitation. Biofizika 22, 518–522 (1977)
Muler, A. L., Markin, V. S.: Electrical properties of anisotropic nerve-muscle syncytia — III. Steady form of the excitation front. Biofizika 22, 671–675 (1977)
Peskoff, A.: Electric potential in three-dimensional electrically syncytial tissues. Bull. Math. Biol. 41, 163–181 (1979)
Peskoff, A.: Electric potential in cylindrical syncytia and muscle fibers. Bull. Math. Biol. 41, 183–192 (1979)
Plonsey, R.: The use of a bidomain model for the study of excitable media. Lect. Math. Life Sci. 21, 123–149 (1989)
Plonsey, R., Barr, R. C.: The four-electrode resistivity technique as applied to cardiac muscle. IEEE Trans. Biomed. Eng. 29, 541–546 (1982)
Plonsey, R., Barr, R. C.: Effect of microscopic and macroscopic discontinuities on the response of cardiac tissue to defibrillating (stimulating) currents. Med. Biol. Eng. Comput. 24, 130–136 (1986)
Plonsey, R., Barr, R. C.: Inclusion of junction elements in a linear cardiac model through secondary sources. Application to defibrillation. Med. Biol. Eng. Comput. 24, 137–144 (1986)
Plonsey, R., Barr, R. C.: Interstitial potentials and their change with depth into cardiac tissue. Biophys. J. 51, 547–555 (1987)
Plonsey, R., Barr, R. C.: Current flow patterns in two-dimensional anisotropic bisyncytia with normal and extreme conductivities. Biophys. J. 45, 557–571 (1984)
Rattay, F.: Ways to approximate current-distance relations for electrically stimulated fibers. J. Theor. Biol. 125, 339–349 (1987)
Roberts, D. E., Hersh, L. T., Scher, A. M.: Influence of cardiac fiber orientation on wavefront voltage, conduction velocity, and tissue resistivity in the dog. Circ. Res. 44, 701–712 (1979)
Roberts, D. E., Scher, A. M.: Effects of tissue anisotropy on extracellular potential fields in canine myocardium in situ. Circ. Res. 50, 342–351 (1982)
Roth, B. J.: The electrical potential produced by a strand of cardiac muscle: A bidomain analysis. Ann. Biomed. Eng. 16, 609–637 (1988)
Roth, B. J.: Action potential propagation in a thick strand of cardiac muscle. Circ. Res. 68, 162–173 (1991)
Roth, B. J., Wikswo, J. P. Jr.: A bi-domain model for the extracellular potential and the magnetic field of cardiac tissue. IEEE Trans. Biomed. Eng. 32, 467–469 (1986)
Roth, B. J., Guo, W.-Q., Wikswo, J. P. Jr.: The effects of spiral anisotropy on the electrical potential and magnetic field at the apex of the heart. Math. Biosci. 88, 159–189 (1988)
Roth, B. J., Gielen, F. L. H.: A comparison of two models for calculating the electrical potential in skeletal muscle. Ann. Biomed. Eng. 15, 591–602 (1987)
Rudy, Y., Quan, W.: A model study of the effects of the discrete cellular structure on electrical propagation in cardiac tissue. Circ. Res. 61, 815–823 (1987)
Sepulveda, N. G., Wikswo, J. P., Jr.: Electric and magnetic fields from two-dimensional anisotropic bisyncytia. Biophys. J. 51, 557–568 (1987)
Sepulveda, N. G., Roth, B. J., Wikswo, J. P., Jr.: Current injection into a two-dimensional anisotropic bidomain. Biophys. J. 55, 987–999 (1989)
Spach, M. S., Miller, W. T., III, Geselowitz, D. B., Barr, R. C., Kootsey, J. M., Johnson, E. A.: The discontinuous nature of propagation in normal canine cardiac muscle. Evidence for recurrent discontinuities of intracellular resistance that affect the membrane currents. Circ. Res. 48, 39–54 (1981)
Tung, L.: A bi-domain model for describing ischemic myocardial d-c potentials. Ph.D. dissertation. Cambridge, Massachusetts: MIT 1978
Wikswo, J. P. Jr., Wisialowski, T. A., Altemeier, W. A., Balser, J. R., Kopelman, H. A., Roden, D. M.: Virtual cathode effects during stimulation of cardiac muscle: Two-dimensional in vivo experiments. Circ. Res. 68, 513–530 (1991)
Winfree, A. T.: Ventricular reentry in three dimensions. In: Zipes, D. P., Jalife, J. (eds.) Cardiac Electrophysiology, From Cell to Bedside, pp. 224–234. Philadelphia: Saunders 1990
Woodbury, J. W., Crill, W. E.: On the problem of impulse conduction in the atrium. In: Lord Florey (ed.) Nervous Inhibition, pp. 124–135. New York: Plenum Press 1961
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Roth, B.J. How the anisotropy of the intracellular and extracellular conductivities influences stimulation of cardiac muscle. J. Math. Biol. 30, 633–646 (1992). https://doi.org/10.1007/BF00175610
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DOI: https://doi.org/10.1007/BF00175610