Abstract
The aim of this study was to assess the pharmacokinetics and tolerance of Gd-DOTA (DOTAREM) in non-dialysed patients with chronic renal failure. Eight patients with chronic renal failure (creatinine clearance between 10 and 60 ml/min) and four healthy volunteers were given i.v. Gd-DOTA (0.1 mmol/kg). Blood and urine samples were collected. Gd-DOTA tolerance was also studied (vital signs, biological parameters, adverse reactions). In healthy volunteers, Gd-DOTA was rapidly distributed in the extracellular space and almost totally eliminated in the urine (glomerular filtration, 93.3±4.7% of the dose 24 h post injection). In patients with chronic renal failure, a delayed and almost total urinary elimination observed with a correlation between Gd-DOTA clearance and plasma creatinine clearance (r = 0.964). Tolerance was good with no significant modification of renal function or other parameters. These results confirm previous studies and indicates that DOTAREM can be used safely for patients with chronic renal failure.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Katzberg RW, Sahler LG, Duda SW, Morris TW, McKennna AB, Pabico RC, Niedrach WL, Tonetti FW (1990) Renal handling and physiologic effects of the paramagnetic contrast medium Gd-Dota. Invest Radiol 25: 714–719
Deray G, Dubois M, Brillet G, Beaufils H, Baumelou B, Jacobs C (1990) Renal tolerance of contrast agents used for resonance magnetic imaging (rmi) (abstract). In: 2ème congrès sur la recherche en imagerie médicale, Bordeaux-France p 96
Doucet D, Chambon C, Brelet F, Josipowicz N (1989) Pharmacokinetics of Gd-Dota and Gd-Dtpa in rats with induced acute renal failure (abstract). In: 17th International congress of radiology (ICR), Paris-France p 187
Deray G, Bellin MF, Baumelou B, Rey JP, Boulechfar H, Grellet J, Jacobs C (1990) Renal tolerance of the paramagnetic contrast medium Gd-Dota in patients with chronic renal failure. Am J Nephrol 10: 522–523
Bellin MF, Deray G, Assogba U, Auberton E, Ghany F, Dion-Voirin E, Jacobs C, Grellet J (1992) Gd-Dota: evaluation of its renal tolerance in patients with chronic renal failure. Magn Reson Imaging, 10: 115–118
Schumann-Giampieri G, Krestin G (1991) Pharmacokinetics of Gd-DTPA in patients with chronic renal failure. Invest Radiol 26: 975–979
Meyer D, Schaefer M, Bonnemain B (1988) Gd-Dota: a potential mri contrast agent current status of physicochemical knowledge. Invest Radiol 23: 232–235
Author information
Authors and Affiliations
Additional information
Correspondence to: A. Chachuat
Rights and permissions
About this article
Cite this article
Chachuat, A., Molinier, P., Bonnemain, B. et al. Pharmacokinetics and tolerance of Gd-DOTA (DOTAREM) in healthy volunteers and in patients with chronic renal failure. Eur. Radiol. 2, 326–329 (1992). https://doi.org/10.1007/BF00175436
Issue Date:
DOI: https://doi.org/10.1007/BF00175436