Abstract
The stretched attend posture (SAP) in the mouse is an investigatory forward elongation of the body in a novel environment. In a previous study, the anxiolytics diazepam, clobazam, and phenobarbital reduced SAP, and low doses of the non-anxiolytics imipramine and chlorpromazine were ineffective, results which prompted the investigator to propose the SAP test as a screening method for anxiolytics. However, diazepam and clobazam also increased immobility. In the present study, the anxiolytics chlordiazepoxide, pentobarbital, and buspirone and behaviorally active doses of the non-anxiolytics chlorpromazine and morphine reduced SAP and tended to increase immobility. We concluded that therapeutic-class specificity has not been demonstrated for the SAP test.
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References
Grant EC, Mackintosh JH (1963) A comparison of the social postures of some common laboratory rodents. Behaviour 21:246–259
Kaesermann HP (1986) Stretched attend posture, a non-social form of ambivalence, is sensitive to a conflict-reducing action. Psychopharmacology 89:31–37
Mason P, Skinner J, Luttinger D (1987) Two tests in rats for antianxiety effect of clinically anxiety attentuating antidepressants. Psychopharmacology 92:30–34
Pollard GT, Howard JL (1986a) The staircase test: Some evidence of nonspecificity for anxiolytics. Psychopharmacology 89:14–19
Pollard GT, Howard JL (1986b) Similar effects of antidepressant and non-antidepressant drugs on behavior under an interresponse-time >72-sec schedule. Psychopharmacology 89:253–258
Simiand J, Keane PE, Morre M (1984) The staircase test in mice: A simple and efficient procedure for primary screening of anxiolytic agents. Psychopharmacology 84:48–53
Van der Poel AM (1967) Ethological study of the behaviour of the albino rat in a “passive-avoidance” test. Acta Physiol Pharmacol Neerl 14:503–504
Van der Poel AM (1979) A note on “stretched attention”, a behavioural element indicative of an approach-avoidance conflict in rats. Anim Behav 27:446–450
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Pollard, G.T., Howard, J.L. Effects of chlordiazepoxide, pentobarbital, buspirone, chlorpromazine, and morphine in the stretched attend posture (SAP) test. Psychopharmacology 94, 433–434 (1988). https://doi.org/10.1007/BF00174704
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DOI: https://doi.org/10.1007/BF00174704