Abstract
Seventeen outpatients were treated with depot neuroleptics, zuclopenthixol decanoate in Viscoleo or fluphenazine decanoate in sesame oil, with dosage intervals of 3 weeks. During the 4th, 6th, and 8th dosage interval blood samples were drawn in oxalated tubes. Plasma concentrations of the active neuroleptic drugs, zuclopenthixol and fluphenazine, were determined by high performance liquid chromatography. The concentrations indicated some interindividual as well as intraindividual variations. For zuclopenthixol the maximum concentration was most often seen at day 7 after injection, whereas the kinetics of the fluphenazine concentrations was more variable. There was an indication of more fluctuation in the 4th dosage interval than in the 8th dosage interval, possibly due to the fact that steady state has not yet been achieved at the 4th dosage interval.
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References
Aaes-Jørgensen T (1980) Specific high performance liquid chromatographic method for estimation of the cis(Z)- and trans(E)-isomers of clopenthixol and a N-dealkyl metabolite. J Chromatogr 183:239–245
Aaes-Jørgensen T, Fredricson Overø, K. Bøgesø KP, Jørgensen A (1977) Pharmacokinetic studies on clopenthixol decanoate; A comparison with clopenthixol in dogs and rats. Acta Pharmacol Toxicol (Copenh) 41:103–120
Aaes-Jørgensen T, Kirk L, Petersen E, Danneskiold-Samsøe P, Jørgensen A (1983) Serum concentrations of the isomers of clopenthixol and a metabolite in patients given cis(Z)-clopenthixol decanoate in Viscoleo. Psychopharmacology 81:68–72
Barnes TRE, Wiles DH (1983) Variation in oro-facial tardive dyskinesia during depot antipsychotic drug treatment. Psychopharmacology 81:359–362
Chang SS, Javaid JI, Dysken MW, Casper RC, Janicak PG, Davis JM (1985) Plasma levels of fluphenazine during fluphenazine decanoate treatment in schizophrenia. Psychopharmacology 87:55–58
Curry SH, Whelpton R, De Schepper PJ, Vrankx C, Schiff AA (1979) Kinetics of fluphenazine after fluphenazine dihydrochloride, enanthate and decanoate administration to man. Br J Clin Pharmacol 7:325–331
Fredricson Overø K (1980) A specific fluorimetric method for assay of drug levels in serum of patients treated with clopenthixol decanoate injections. Acta Psychiatr Scand [Suppl 279] 61:92–103
Jørgensen A, Fredricson Overø K (1980) Clopenthixol and flupentixol depot preparations in outpatient schizophrenics. III. Serum levels. Acta Psychiatr Scand [Suppl 279] 61:41–54
Marder SR, Hawes EM, Van Putten T, Hubbard JW, McKay G, Mintz J, May PRA, Midha KK (1986) Fluphenazine plasma levels in patients receiving low and conventional doses of fluphenazine decanoate. Psychopharmacology 88:480–483
Svendsen O, Aaes-Jørgensen T (1979) Studies on the fate of vegetable oil after intramuscular injection into experimental animals. Acta Pharmacol Toxicol 45:353–378
Viala A, Nhean Hou, Durand A, Ba B, Aaes-Jørgensen T, Jørgensen A (1983) Dosage du cis(Z)-clopenthixol et de la fluphénazine dans le sang total et le plasma par chromatographie en phase liquide a haute performance avec étalonnage interne. J Pharm Belg 38:299–303
Viala A, Nhean Hou Ba B, Durand A, Dufour H, D'Agostino N, Berda C, Jørgensen A (1984) Blood and plasma kinetics of cis(Z)-clopenthixol and fluphenazine in psychiatric patients after intramuscular injection of their decanoic esters. Psychopharmacology 83:147–150
Wiles DH, Gelder MG (1979) Plasma fluphenazine levels by radioimmunoassay in schizophrenic patients treated with depot injection of fluphenazine decanoate. Br J Clin Pharmacol 8:565–570
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Viala, A., Ba, B., Durand, A. et al. Comparative study of the pharmacokinetics of zuclopenthixol decanoate and fluphenazine decanoate. Psychopharmacology 94, 293–297 (1988). https://doi.org/10.1007/BF00174677
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DOI: https://doi.org/10.1007/BF00174677