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Histometry and three-dimensional image reconstruction of the lung in congenital diaphragmatic hernia

Pediatric Surgery International volume 11, pages 29–32 (1996)Cite this article

Abstract

A small lung capacity, hypoplasia of the airway system, and abnormalities of the pulmonary artery system have been demonstrated as pathologic characteristics of congenital diaphragmatic hernia, but opinions have differed on the degree of hypoplasia of the acinus and terminal airspace. In this study, acinar size, mean wall thickness of the terminal airspace, an surface area of the terminal airspace were histometrically evaluated in four clinical cases. In addition, the pulmonary artery system was investigated by computerized three dimensional image reconstruction. Hypoplasia of the lung acinus and terminal airspace was observed in all four cases, and hypoplasia was more marked as lung capacity decreased. Thickening of the walls of pulmonary arterioles was confirmed, and previously undescribed abnormal branching of the pulmonary artery was recorded.

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References

  1. Campanale RP, Rowland RH (1955) Hypoplasia of the lung associated with congenital diaphragmatic hernia. Ann Surg 142: 176–189

    PubMed  Article  CAS  Google Scholar 

  2. Moore TC, Battersby JS, Roggenkamp MW (1957) Congenital posterolateral diaphragmatic hernia in the newborn. Surg Gynecol Obstet 104: 675–689

    PubMed  CAS  Google Scholar 

  3. Kieswetter WB, Gutierrez IZ, Sieber WK (1961) Diaphragmatic hernia in infants under one year of age. Arch Surg 83: 561–572

    Article  Google Scholar 

  4. Butler N, Claireaux AE (1962) Congenital diaphragmatic hernia. Lancet I: 659–663

    Article  Google Scholar 

  5. Areechon W, Reid V (1963) Hypoplasia of lung with congenital diaphragmatic hernia. Br Med J 1: 230–233

    PubMed  Article  CAS  Google Scholar 

  6. Kitagawa M, Hislop A, Boyden EA, et al (1971) Lung hypoplasia in congenital diaphragmatic hernia. Br J Surg 58: 342–346

    PubMed  Article  CAS  Google Scholar 

  7. Boyden EA (1972) The structure of compressed lungs in congenital diaphragmatic hernia. Am J Anat 134: 497–507

    PubMed  Article  CAS  Google Scholar 

  8. Hisco A, Reid L (1976) Persistent hypoplasia of the lung after repair of congenital diaphragmatic hernia. Thorax 31: 450–455

    Article  Google Scholar 

  9. Levin DL (1978) Morphologic analysis of the pulmonary vascular bed in congenital left-sided diaphragmatic hernia. J Pediatr 92: 805–809

    PubMed  Article  CAS  Google Scholar 

  10. Kato T, Hebiguchi T, Matsuda K, et al (1984) Clinical and experimental studies on hypoplastic lung in congenital diaphragmatic hernia. Jpn J Pediatr Surg, 16: 1405–1416

    Google Scholar 

  11. Saito M, Saito K (1985) Histometrical analysis on intrauterine growth and development of the lung acinus in rabbits, Acta Neonat Jap 21: 353–360

    Google Scholar 

  12. Chalkley HW (1943) Method for the quantitative morphologic analysis of tissues, J Natl Cancer Inst 4: 47–53

    Google Scholar 

  13. Cahlkley H, Cornfield J, Park H (1949) A method for estimating volume-surface ratios. Science 110: 295–297

    Article  Google Scholar 

  14. Saito M, Saito K (1985) Histometrical evaluation of the degree of lung growth and development of human premature babies. Acta Neonat Jap 21: 361–368

    Google Scholar 

  15. Wigglesworth JS, Desai R (1981) Use of DNA estimation for growth assessment in normal and hypoplastic fetal lungs. Arch Dis Child 56: 601–605

    PubMed  Article  CAS  Google Scholar 

  16. Davies G, Reid L (1970) Growth of the alveoli and pulmonary arteries in childhood. Thorax 25: 669–681

    PubMed  Article  CAS  Google Scholar 

  17. Murphy JD, Rabiinovitch M, Goldstein JD et al. (1971) The structural basis of persistent pulmonary hypertension of the newborn infant. J Pediatr 98: 962–967

    Google Scholar 

  18. Reale FR, Esterly JR (1973) Pulmonary hypoplasia, a morphometric study of the lungs of infants with diaphragmatic hernia, anencephaly and renal malformations. Pediatrics 51: 91–96

    PubMed  CAS  Google Scholar 

  19. Naeye RL, Shochat SJ, Whitman V, et al. (1976) Unsuspected pulmonary vascular abnormalities associated with diaphragmatic hernia. Pediatries 58: 902–906

    CAS  Google Scholar 

  20. Langston C, Thurlbeck WM (1982) Lung growth and development in late gestation and early postnatal life. In: Rosenberg HS, Bernstein J (eds) Perspectives in pediatric pathology. Masson, New York, pp 203–235

    Google Scholar 

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Affiliations

  1. First Department of Surgery, Akita University School of Medicine, 1-1-1 Hondo, 010, Akita, Japan

    Tetsuo Kato, Hiroaki Yoshino, Kiyoshi Matsuda, Takatsugu Murakoshi, Tatsuzo Hebiguchi & Kenji Koyama

  2. Department of Pathology, Akita University School of Medicine, Akita, Japan

    Masahiro Saito & Ken Saito

Authors
  1. Tetsuo Kato
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  2. Hiroaki Yoshino
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  3. Kiyoshi Matsuda
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  4. Takatsugu Murakoshi
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  5. Tatsuzo Hebiguchi
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  6. Kenji Koyama
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  7. Masahiro Saito
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  8. Ken Saito
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Kato, T., Yoshino, H., Matsuda, K. et al. Histometry and three-dimensional image reconstruction of the lung in congenital diaphragmatic hernia. Pediatr Surg Int 11, 29–32 (1996). https://doi.org/10.1007/BF00174581

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  • DOI: https://doi.org/10.1007/BF00174581

Key words

  • Congenital diaphragmatic hernia
  • Pulmonary hypoplasia
  • Histometry
  • Three-dimensional image reconstruction