Abstract
The amnesic action of phencyclidine (PCP) was investigated in mice using a passive avoidance- and escape-learning method. PCP (10–30 mg/kg) administered immediately after the training test dose-dependently shortened and prolonged the step-down latency and escape latency, respectively in the retention test. There was a significant inverse relationship between the step-down and escape latencies, indicating that PCP had induced amnesia. The amnesic actions of PCP were retrograde, being observed when mice were given PCP within 10 min but not more than 30 min after the training test. The amnesic effects of PCP on both variables were antagonized significantly by physostigmine and naloxone, whereas cyproheptadine and haloperidol had no effect. None of these drugs by themselves affected passive avoidance- or escape-learning performance. These results suggest that the retrograde amnesic actions of PCP were produced via either the cholinergic or the opioidergic systems or both, but not through the serotonergic and the dopaminergic systems.
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References
Baratti CM, Introini IB, Huygens P (1984) Possible interaction between central muscarinic and opioid peptidergic systems during memory consolidation in mice. Behav Neural Biol 40:155–169
Burns RS, Lerner SE (1976) Perspective: Acute phencyclidine intoxication. Clin Toxicol 9:477–501
Carrasco MA, Dias RD, Perry MLS, Wofchuk ST, Souza DO, Izquierdo I (1982) Effect of morphine, ACTH, epinephrine, Met-, Leu- and des-Tyr-Met-enkephalin on β-endorphin-like immunoreactivity of rat brain. Psychoneuroendocrinology 7:229–234
Chen G (1958) Pharmacology of 1-(1-phenylcyclohexyl) piperidine-HCl. Fed Proc 17:358
Deutsch JA, Rocklin KW (1967) Amnesia induced by scopolamine and its temporal variations. Nature (Lond) 216:89–90
Deutsch DG, Koul O, Kersten SK (1984) Phencyclidine and analogues: Effects on brain protein synthesis. J Neurochem 42:407–411
Domino EF, Luby ED (1973) Abnormal mental states induced by phencyclidine as a model of schizophrenia. In: Cole JO, Freeman AM, Friedhoff AJ (eds) Psychopathology and psychopharmacology. Johns Hopkins Press, pp 37–50
Glick SD, Zimmerberg B (1971) Comparative learning impairment and amnesia by scopolamine, phencyclidine and ketamine, Psychon Sci 25:165–166
Henderson G (1982) Phencyclidine, a widely abused but little understood psychotomimetic agent. TIPS 3:248–250
Hiramatsu M, Nabeshima T, Furukawa H, Kamayama T (1984) Effects of enkephalin analogs, morphine and naloxone on the behavioral responses of phencyclidine in mice. Res Commun Subst Abuse 5:161–174
Hiramatsu M, Nabeshima T, Kameyama T (1986) Involvement of opioid receptors in hypo- and hyperthermic effects induced by phencyclidine in mice. J Pharmacobio Dyn 9 (in press)
Hiramastu M, Nabeshima T, Furukawa H, Kameyama T (1986) Potentiation of phencyclidine-induced stereotyped behaviors in rats by thiorphan and bestatin. Eur J Pharmacol 120:69–74
Holtzman SG (1980) Phencyclidine-like discriminative effects of opioids in the rat. J Pharmacol Exp Ther 214:614–619
Introini IB, Baratti CM (1984) The impairment of retention induced by β-endorphin in mice may be mediated by a reduction of central cholinergic activity. Behav Neural Biol 41:152–163
Izquierdo I (1982) β-Endorphin and forgetting. TIPS 40:455–457
Izquierdo I, Dias RD (1983) Effects of epinephrine, β-endorphine, naloxone, the combination of naloxone or β-endorphine with ACTH or epinephrine on memory consolidation. Psychoneuroendocrinology 8:81–87
Kameyama T, Nabeshima T, Kozawa T (1986) Step-down type passive avoidance- and escape-learning method: suitability for experimental amnesia models. J Pharmacol Method (in press)
Nabeshima T, Hiramatsu M, Amano M, Furukawa H, Kameyama T (1983a) Decrease of methionin-enkephalin level in mouse brain induced by phencyclidine. Eur J Pharmacol 86:271–273
Nabeshima T, Hiramatsu M, Amano M, Furukawa H, Kameyama T (1983b) Chronic phencyclidine increases methionine-enkephalin level in mouse striatum. Neurosci Lett 37:69–74
Nabeshima T, Sivam SP, Ho IK (1983c) Effect of morphine on the responses to and disposition of phencyclidine in mice. I. Enhancement of phencyclidine effects by acute morphine administration. J Pharmacol Exp Ther 225:325–331
Nabeshima T, Yamada K, Yamaguchi K, Hiramatsu M, Furukawa H, Kameyama T (1983d) Effect of lesions in the striatum, nucleus accumbens and medial raphe on phencyclidine-induced stereotyped behaviors and hyperactivity in rats. Eur J Pharmacol 91:455–462
Nabeshima T, Yamaguchi K, Yamada K, Hiramatsu M, Furukawa H, Kameyama T (1983e) Phencyclidine-induced stereotyped behaviors in rats following specific neurotoxin lesions of the striatum. Eur J Pharmacol 93:229–234
Nabeshima T, Furukawa H, Kameyama T (1984a) Phencyclidine, the drug induces psychosis: Its neuropharmacological actions. Jpn. J Psychopharmacol 4:133–147
Nabeshima T, Yamaguchi K, Hiramatsu M, Amano M, Furukawa H, Kameyama T (1984b) Serotonergic involvement in phencyclidine-induced stereotyped behaviors. Pharmacol Biochem Behav 21:401–408
Nabeshima T, Hiramatsu M, Furukawa H, Kameyama T (1985) Effects of phencyclidine in combination with morphine on the levels of met-enkephalin, dopamine, DOPAC and HVA in discrete brain areas of mice. Neuropharmacology 24:805–809
Perry EK, Perry RH, Blessed G (1977) Necropsy evidence of central cholinergic deficits in senile dementia. Lancet 1:189
Vincent JP, Caver D, Kamenka JM, Geneste P, Lazdunski M (1978) Interaction of phencyclidine with the muscarinic and opiate receptors in the central nervous system. Brain Res 214:614–619
Zukin RS, Zukin SR (1983) A common receptor for phencyclidine and the sigma opiates. In: Kamenka JM, Domino EF, Geneste P (eds) Phencyclidine and related arylcyclohexylamines: Present and future applications. NPP Books, Ann Arbor, pp 107–124
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Nabeshima, T., Kozawa, T., Furukawa, H. et al. Phencyclidine-induced retrograde amnesia in mice. Psychopharmacology 89, 334–337 (1986). https://doi.org/10.1007/BF00174370
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DOI: https://doi.org/10.1007/BF00174370