Abstract
An experimental rat model for the study of venous pain induced by 4-hydroxy-cyclophosphamide (4-OH-CP) derivatives was developed and validated. Using various metabolites and chemical variants of 4-OH-CP it was found that pain induction was independent from the compound's alkylating activity but possibly related to the spontaneous generation of minute amounts of acrolein from the 4-OH-CP molecule. Accordingly, the pain could be prevented by the addition of thiol compounds such as mesna or N-acetyl-cysteine.
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Hilgard, P., Pohl, J. Short communication: Cause and prevention of mafosfamide-induced venous pain. Invest New Drugs 4, 373–376 (1986). https://doi.org/10.1007/BF00173510
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DOI: https://doi.org/10.1007/BF00173510