Abstract
Proteins, on binding to a DNA sequence, alter the frequency and quality of mutations that occur in the sequence. This represents a reverse flow of information from proteins to DNA. Nucleosome binding causes patterns of UV-induced damage which, when converted to mutations by replication, will phase nucleosomes. We propose that DNA binding proteins create their own high- or low-affinity binding sites along DNA sequences by biased mutational pressure.
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Holmquist, G.P. Chromatin self-organization by mutation bias. J Mol Evol 39, 436–438 (1994). https://doi.org/10.1007/BF00173411
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DOI: https://doi.org/10.1007/BF00173411