Abstract
A neonate underwent resection of an extensive sacrococcygeal teratoma after receiving a bolus of 40,000 Kallikrein Inhibitory Units of aprotinin at induction of anaesthesia. The measured blood loss was 30 ml, less than 10% of blood volume, and was replaced with an intravenous colloid solution, avoiding blood transfusion. The blood loss was low compared to previous resections of similar sacrococcygeal teratomas (mean 118 ml, range 60–250 ml) and suggests that aprotinin may be beneficial in blood conservation during extensive dissections in infants.
Similar content being viewed by others
References
Altman RP, Randolph JG, Lilley JR (1974) Sacrococcygeal teratoma: American Acadamy of Pediatrics Surgical Section Survey — 1973. J Pediatr Surg 9: 389–398
Elliott MJ, Allen A (1990) Aprotinin in paediatric cardiac surgery. Perfusion 5: 73–76
Harder MP, Eijsman L, Roozendaal KJ, van Oeveren W, Wildevuur CR (1991) Aprotinin reduces intraoperative and postoperative blood loss in membrane oxygenator cardiopulmonary bypass. Ann Thorac Surg 51: 936–941
Hunt BJ, Cottam S, Segal H, Ginsberg R, Potter D (1990) Inhibition by aprotinin of tPA-mediated fibrinolysis during orthotopic liver transplantation. Lancet 336: 381
Hunt BJ, Yacoub M (1991) Aprotinin and cardiac surgery. Br Med J 303: 660–661
Mallett SV, Cox D, Burroughs AK, Rolles K (1990) Aprotinin and reduction of blood loss and transfusion requirements in orthotopic liver transplantation. Lancet 336: 886–887
Neuhaus P, Bechstein WO, Lefèbre B, Blumhardt G, Slama K (1989) Effect of aprotinin on intraoperative bleeding and fibrinolysis in liver transplantation. Lancet II 924–925
Royston D, Bidstrup BP, Taylor KM, Sapsford RN (1987) Effect of aprotinin on need for blood transfusion after repeat open heart surgery. Lancet ii 1289–1291
Shanbhogue LKR, Bianchi A, Doig CM, Gough DCS (1990) Management of benign sacrococcygeal teratoma: reducing mortality and morbidity. Pediatr Surg Int 5: 41–44
Thompson JF, Roath OS, Francis JL, Webster JHH, Chant ADB (1990) Aprotinin in peripheral vascular surgery. Lancet 335: 911
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Morecroft, J.A., Lander, A.D., Sury, M.R.J. et al. Sacrococcygeal teratoma: improved haemostasis after aprotinin?. Pediatr Surg Int 8, 366–367 (1993). https://doi.org/10.1007/BF00173370
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00173370