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Pitfalls in scintigraphic detection of neuroendocrine tumours

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Abstract

We report 4 cases of abnormal results using iodine-123 metaiodobenzylguanidine (123I-mIBG) or technetium-99m (V) dimercaptosuccinic acid (99mTc(V)-DMSA) scintigraphy in the diagnosis and follow-up of presumed neuroendocrine tumours. The present series consisted of 2 false-positive cases (1 adenomatous polyp of the caecum with mIBG and 1 follicular adenoma of the thyroid with DMSA) and 2 cases of anomalous uptake of (V)-DMSA in a non-neuroendocrine tissue.

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References

  • Clarke SEM, Lazarus CR, Wright P, et al (1988) Pentavalent 99mTc-DMSA, 131I-mIBG and 99mTc-MDP — an evaluation of three imaging techniques in patients with medullary carcinoma of the thyroid. J Nucl Med 29:33–38

    Google Scholar 

  • Endo K, Shiomi K, Kasagai K, et al (1984) Imaging of medullary thyroid cancer with 131I-mIBG. Lancet II:233

    Google Scholar 

  • Fischer M, Kamanabroo D, Sanderkamp H, et al (1985) Scintigraphic imaging of carcinoid tumours with 131I-mIBG. Lancet II:165

    Google Scholar 

  • Harbert GC (1987) Meta-131–1-iodobenzylguanidine therapy of malignant pheochromocytomas and other neuroendocrine lesions. In: Nuclear medicine therapy. Thieme, New York, p 99

    Google Scholar 

  • Hilditch TE, Connel J, Elliot AT, et al (1986) Poor results with technetium-99m(V)DMSA and iodine-131 MIBG in the imaging of medullary thyroid carcinoma. J Nucl Med 27:1150–1153

    Google Scholar 

  • Hoefnagel CA, Voute PA, De Kraker J, et al (1987) Radionuclide diagnosis and therapy of neural crest tumours using iodine-131 metaiodobenzylguanidine. J Nuel Med 28:308–314

    Google Scholar 

  • Moll L von, McEwan AJ, Shapiro B, et al (1987) Iodine-131 MIBG scintigraphy of neuroendocrine tumours other than pheochromocytoma and neuroblastoma. J Nucl Med 28:979–988

    Google Scholar 

  • Otha H, Yamamoto K, Endo K, et al (1984) A new imaging agent for medullary carcinoma of the thyroid. J Nucl Med 25:323–325

    Google Scholar 

  • Otha T, Endo K, Fujita T, et al (1988) Clinical evaluation of tumor imaging using 99Tc(V)m dimercaptosuccinic acid, a new tumor-seeking agent. Nucl Med Commun 9:105–116

    Google Scholar 

  • Prandini N, Trasforini G, Feggi L, et al (1989) 123-I-Metaiodobenzylguanidine uptake in an adenomatosus polyp of the colon. J Nucl Med Allied Sci 33:188

    Google Scholar 

  • Shapiro B, Copp JE, Sisson JC, et al (1985) Iodine-131 metaiodobenzylguanidine for the locating of suspected pheochromocytoma: experience in 400 cases. J Nucl Med 26:576–585

    Google Scholar 

  • Sisson JC, Frager MC, Valk TW, et al (1981) Scintigraphic localization of pheochromocytoma. N Engl J Med 305:12–17

    Google Scholar 

  • Troncone L, Rufini V, Danza FM, et al (1990) Radioiodinated metaiodobenzylguanidine (*I-MIBG) scintigraphy in neuroblastoma: a review of 160 studies. J Nucl Med Allied Sci 34:279–288

    Google Scholar 

  • Wulfrank DA, Schelstraete KH, Small F, et al (1989) Analogy between tumor uptake of technetium(V)99m-DMSA and technetium99m-MDP. Clinical Nucl Med 8:588–593

    Google Scholar 

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Workin part presented at the International Congress G.R.A.D.O. 4 Rome, 10–11 May 1991

Offprint requests to: L. Feggi, 1, via Poledrelli, I-44100 Ferrara, Italy

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Feggi, L., Uberti, E.D., Pansini, G.C. et al. Pitfalls in scintigraphic detection of neuroendocrine tumours. Eur J Nucl Med 19, 214–218 (1992). https://doi.org/10.1007/BF00173284

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  • DOI: https://doi.org/10.1007/BF00173284

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