Abstract
In longitudinal muscle/myenteric plexus preparations of the guinea-pig ileum, exogenous nitric oxide (NO) induced concentration-dependent relaxations. In tissues at basal tone, NO (3 × 10−6 M) induced a moderate relaxation followed by a pronounced contraction, consisting of a quick and sustained component. Tetrodotoxin (5 × 10−7 M) abolished both phases of the contraction. Atropine (5 × 10−7 M) abolished the quick component and reduced the sustained component of the contraction; the latter was further suppressed by the selective NK1 receptor antagonist CP 96,345. Hexamethonium (5 × 10−5 M) failed to affect the contractile response to NO. It is concluded that administration of exogenous NO in the guinea-pig ileum can lead to activation cholinergic and to a lesser degree tachykininergic neurones.
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Correspondence to: L. Barthó at the above address
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Barthó, L., Lefebvre, R. Nitric oxide induces acetylcholine-mediated contractions in the guinea-pig small intestine. Naunyn-Schmiedeberg's Arch Pharmacol 350, 582–584 (1994). https://doi.org/10.1007/BF00173030
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DOI: https://doi.org/10.1007/BF00173030