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Immunophenotypic profile of CNS lymphoma: A review of eighteen cases

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Summary

The cell surface antigenic phenotype of 18 cases of central nervous system (CNS) large-cell lymphoma (14 primary, four secondary) was examined by an immunoperoxidase technique using antibodies that identify B cell restricted and associated antigens. All cases were shown to be of B cell origin by virtue of the expression of monotypic immunoglobulin (Ig) (16 IgM, two IgG) and the pan B cell antigen B1 ( CD20). A panel of monoclonal antibodies directed against B cell restricted and associated activation antigens including B5, Blast-1, Blast-2 (CD23), BB1, interleukin 2 receptor (IL2R, CD25), T9 (transferrin receptor) and TNK-TAR (4F2) was used on 12 of the cases. The majority expressed T9 and TNK-TAR. Blast-1 was expressed by less than half the cases and Blast-2 and B5 by one of 12 cases each. This is in contrast to 10 non-CNS diffuse large cell lymphomas where B5 and Blast-1 were present on all cases. This study confirms previous observations that primary CNS large cell lymphomas are of B cell derivation. Moreover, the differences in expression of B cell activation antigens on CNS large cell lymphomas as compared to non-CNS lymphomas raise the possibility that a subset of neoplastic B cells may have unique tropism for the CNS.

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Authors and Affiliations

  1. Division of Neurology, University of Nebraska Medical Center, USA

    R. Bashir, K. Bain & F. Hochberge

  2. Departments of Neurology and Pathology, Massachusetts General Hospital, USA

    N. Harris

  3. Division of Tumor Immunology, Dana Farber Cancer Institute, USA

    A. Freedman & L. Nadler

Authors
  1. R. Bashir
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  2. A. Freedman
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  3. N. Harris
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  4. K. Bain
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  5. L. Nadler
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  6. F. Hochberge
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Additional information

Supported by a fellowship of the Association of Brain Tumor Research, the Narragansett Foundation and the Anne Blittner and James Smith Funds.

Supported by PHS grant 5K08 CA 01105-01. Awarded by National Cancer Institute, DHHS and by National Institute of Health Grant CA 40216.

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Bashir, R., Freedman, A., Harris, N. et al. Immunophenotypic profile of CNS lymphoma: A review of eighteen cases. J Neuro-Oncol 7, 249–254 (1989). https://doi.org/10.1007/BF00172918

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