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Mucormycosis: a deadly disease with a new treatment

  • Rare Pathological Conditions
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European Journal of Plastic Surgery Aims and scope Submit manuscript

Abstract

Mucormycosis (zygomycosis, phycomycosis) is the most acutely fatal fungal infection in humans. It is a rare condition and any one person's experience with the condition is limited to a few cases at most. A patient with advanced rhino-orbitocerebral mucormycosis who survived after debridement and free flap transfer is presented. It is proposed that a free flap may provide the ideal environment for combatting this condition by providing an increased blood supply and an effective delivery system for antimicrobial agents.

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References

  1. Daly AL, Velazquez LA, Bradley SF, Kauffman CA (1989) Mucormycosis: association with deferoxamine therapy. Am J Med 87:468–471

    Google Scholar 

  2. Bhattacharya AK, Deshpande AR, Nayak AR et al (1992) Rhinocerebral mucormycosis: an unusual case presentation. J Laryngol Otol 106:48–49

    Google Scholar 

  3. Sanchez MR, Ponge-Wilson I, Moy JA et al (1994) Zygomycosis and HIV infection. J Am Acad Dermatol 30:904–908

    Google Scholar 

  4. Bodenstein NP, McIntosh WA, Vlantis AC et al (1993) Clinical signs of orbital ischemia in rhino-orbitocerebral mucormycosis. Laryngoscope 103:1357–1361

    Google Scholar 

  5. Moll GW Raila FA, Liu GC et al (1994) Rhinocerebral mucormycosis in IDDM. Sequential magnetic resonance imaging of long-term survival with intensive therapy. Diabetes Care 17:1348–1353

    Google Scholar 

  6. Terk MR, Underwood DJ, Zee CS et al (1992) MR imaging in rhinocerebral and intracranial mucormycosis with CT and pathologic correlation. Magn Reson Imag 10:81–87

    Google Scholar 

  7. Lehrer RL et al (1980) Mucormycosis. Ann Intern Med 93: 93–108

    Google Scholar 

  8. Yohai RA, Bullock JD, Aziz AA et al (1994) Survival factors in rhino-orbitocerebral mucormycosis. Surv Ophthalmol 39: 3–22

    Google Scholar 

  9. Sugar AM (1992) Mucormycosis. Clin Infect Dis 14: S126-S129

    Google Scholar 

  10. Jurgens MA et al (1994) Mucormicosis nasosinusal: una forma clinica benigna. Presentacion de un caso. Acta Otorhinolaringol Esp 45:117–120

    Google Scholar 

  11. de Biscop J, Mondie J, Venries de la Guillauinie B et al (1991) Mucormycosis in an apparently normal host. J Craniomaxillofac Surg 19:275–278

    Google Scholar 

  12. Sponsler TA, Sassani JW, Johnson LN et al (1992) Ocular invasion in mucormycosis. Surv Ophthalmol 36:345–350

    Google Scholar 

  13. Ferry AP, Abedi S (1983) Diagnosis and management of rhino-orbitocerebral mucormycosis (phycomycosis). A report of 16 personally observed cases. Ophthalmology 90:1096–1104

    Google Scholar 

  14. Abedi E, Sismanis A, Choi K et al (1984) Twenty-five years' experience treating cerebro-rhino-orbital mucormycosis. Laryngoscope 94:1060–1062

    Google Scholar 

  15. Fisher EW Toma A, Fisher PH et al (1991) Rhinocerebral mucormycosis: use of liposomal amphotericin-B. J Laryngol Otol 105:575–577

    Google Scholar 

  16. Choi HY, Lew JM, Jackson IT (1992) Rhinocerebral mucormycosis combined with brain abscess. A case report. Eur J Plast Surg 15:146–150

    Google Scholar 

  17. Boelaert JR (1994) Mucormycosis (zygomycosis): is there news for the clinician? J Infect 28:1–6

    Google Scholar 

  18. Economopolou P, Laskaris G, Ferekidis E et al (1995) Rhinocerebral mucormycosis with severe oral lesions: a case report. J Oral Maxillofac Surg 53:215–217

    Google Scholar 

  19. De la Paz MA, Patrinely JR, Marines HM et al (1992) Adjunctive hyperbaric oxygen in the treatment of bilateral cerebro-rhino-orbital mucormycosis. Am J Ophthalmol 114:208–211

    Google Scholar 

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Callan, P.P., Jackson, I.T., Drelichman, V.S. et al. Mucormycosis: a deadly disease with a new treatment. Eur J Plast Surg 19, 275–278 (1996). https://doi.org/10.1007/BF00171887

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  • DOI: https://doi.org/10.1007/BF00171887

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