Abstract
Congenital sinuses of the lower lip in association with cleft lip, cleft palate, or both, are rare and occur in the Van der Woude syndrome. This syndrome is believed to be due to an autosomal dominant gene with 80 to 100% penetrance and a variable expressivity. Five patients with Van der Woude syndrome are presented and the penetrance in the families is examined.
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Bauer BS, Vicari FA (1992) Cleft palate. In: Georgiade GS (ed) Textbook of plastic, Maxillofacial and reconstructive surgery. Williams & Wilkins, Baltimore
Cervenka J, Gorling RJ, Andersen VE (1967) The syndrome of pits of the lower lip and cleft lip/or palate. Genetic considerations. Am J Hum Genet 19:416
Coccia CT, Bixler D (1967) Cleft lip cleft palate and congenital fistulas of the lower lip. Report of a familial occurrence. Oral Surg 24:248
Johnston MC, Bronsky PT, Millicovsky G (1990) Embryogenesis of cleft lip and palate. In: McCarthy JG (ed). Plastic surgery. Saunders, Philadelphia
Shprintzen RJ, Siegel-Sadewitz VL, Amato J, Goldberg RB (1985) Anomalies associated with cleft lip, cleft palate or both. Am J Med Genet 20:585
Taylor WB, Lane DK (1966) Congenital fistulas of lower lip. Arch Dermatol 94:421
Van der Woude A (1954) Fistula labii inferioris congenita and its association with cleft lip and palate. Am J Hum Genet 6:24
Warbrick JG, McIntyre JR, Girdwood-Fergusson A (1952) Remarks on the aetiology of congenital bilateral fistulae of the lower lip. Br J Plast Surg 4:254
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Karacaoğlan, N., Uysal, A. & Türkgüven, Y. Van der Woude syndrome: report on five patients. Eur J Plast Surg 19, 272–274 (1996). https://doi.org/10.1007/BF00171886
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DOI: https://doi.org/10.1007/BF00171886