Skip to main content
SpringerLink
Log in

Tcrb-V12-specific superantigens encoded by mouse mammary tumor proviruses

  • Gene-antigen Register
  • Published:
Immunogenetics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Acha-Orbea, H., Shakhov, A. N., Scarpellino, L., Kolb, E., Muller, V., Vessaz-Shaw, A., Fuchs, R., Blochlinger, K., Rollini, P., Billotte, J., Sarafidou, M., MacDonald, H. R., and Diggelmann, H. Clonal deletion of Vβ14-bearing T cells in mice transgenic for mammary tumour virus. Nature 350: 207–211, 1991

    Google Scholar 

  • Acha-Orbea, H., Scarpellino, L., Shakhov, A. N., Held, W., and MacDonald, H. R. Inhibition of mouse mammary tumor virus-induced T cell responses by antibodies to an open reading frame protein. J Exp Med 176: 1769–1772, 1992

    Google Scholar 

  • Callahan, R., Drohan, V., Gallahan, D., D'Hoostelaere, L., and Potter, M. Novel class of mouse mammary tumor virus-related DNA sequences found in all species of Mus, including mice lacking the virus proviral genome. Proc Natl Acad Sci USA 79: 4113–4117, 1982

    Google Scholar 

  • Choi, Y., Kappler, J. W., and Marrack, P. A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumour virus. Nature 350: 203–207, 1991

    Google Scholar 

  • Choi, Y., Marrack, P., Kappler, J. W. Structural analysis of a mouse mammary tumour virus superantigen. J Exp Med 175: 847–852, 1992

    Google Scholar 

  • Dyson, P. J., Knight, A. M., Fairchild, S., Simpson, E., and Tomonari, K. Genes encoding ligands for deletion of Vβ11 T cells co-segregate with mouse mammary tumor virus genomes. Nature 349: 531–532, 1991

    Google Scholar 

  • Hodes, R. J., Novick, M. B., Palmer, L. D., and Knepper, J. E. Association of a Vβ2-specific superantigen with a tumorigenic milkborne mouse mammary tumor virus. J Immunol 150: 1422–1428, 1993

    Google Scholar 

  • Kappler, J. W., Staerz, U., White, J., and Marrack, P. C. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332: 35–40, 1988

    Google Scholar 

  • MacDonald, H. R., Schneider, R., Lees, R. K., Howe, R. C., Acha-Orbea, H., Festenstein, H., Zinkernagel, R. M., and Hengartner, H. T-cell receptor Vβ use predicts reactivity and tolerance to Mls a encoded antigen. Nature 332: 40–45, 1988

    Google Scholar 

  • Mohan, N., Mottershead, D., Subramanyam, M., Beutner, U., and Huber, B. T. Production and characterization of an Mls-1 specific monoclonal antibody. J Exp Med 177: 351–358, 1993

    Google Scholar 

  • Pullen, A. M., Choi, Y., Kushnir, E., Kappler, J., and Marrack, P. The open reading frames in the 3′ long terminal repeats of several mouse mammary tumor virus integrants encode Vβ3-specific superantigens. J Exp Med 175: 41–47, 1992

    Google Scholar 

  • Tomonari, K. and Fairchild, S. The genetic basis of negative selection of Tcrb-V11+ T cells. Immunogenetics 33: 157–162, 1991

    Google Scholar 

  • Tomonari, K., Fairchild, S., and Rosenwasser, O. A. Influence of viral superantigens on Vβ and Vα-specific positive and negative selection. Immunol Rev 131: 131–168, 1993

    Google Scholar 

  • Tomonari, K. and Lovering, E. T-cell receptor-specific monoclonal antibodies against a Vβ11-positive mouse T cell clone. Immunogenetics 28: 445–451, 1988

    Google Scholar 

  • Tomonari, K. and Spencer, S. Epitope-specific binding of CD8 regulates activation of T cells and induction of cytotoxicity. Int Immunol 2: 1189–1194, 1990

    Google Scholar 

  • Tsiagbe, V. K., Yoshimoto, T., Asakawa, J., Cho, S. Y., Meruelo, D., and Thorbecke, G. J. Linkage of superantigen-like stimulation of syngeneic T cells in a mouse model of follicular center B cell lymphoma to transcription of endogenous mammary tumor virus. EMBO J, in press, 1993

  • Vacchio, M. S., Ryan, J. J., and Hodes, R. J. Characterization of the ligand(s) responsible for negative selection of Vβ11- and Vβ12-expressing T cells: effect of a new Mls determinant. J Exp Med 172: 807–813, 1990

    Google Scholar 

  • Winslow, G. M., Scherer, M. T., Kappler, J. W., and Marrack, P. Detection and biochemical characterization of the mouse mammary tumor virus 7 superantigen (Mls-1a). Cell 71: 719–730, 1992

    Google Scholar 

  • Woodland, D. L., Happ, M. P., Gollob, K. J., and Palmer, E. An endogenous retrovirus mediating deletion of αβT cells? Nature 349: 529–530, 1991

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Immunological Medicine, MRC Clinical Research Centre, Watford Road, HA1 3UJ, Harrow, Middlesex, UK

    Kyuhei Tomonari

Authors
  1. Kyuhei Tomonari
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tomonari, K. Tcrb-V12-specific superantigens encoded by mouse mammary tumor proviruses. Immunogenetics 39, 65–67 (1994). https://doi.org/10.1007/BF00171800

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00171800

Keywords

Search

Navigation