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Histamine and leukotriene C4 effects on in vitro ciliary beat frequency of human upper respiratory cilia

European Archives of Oto-Rhino-Laryngology volume 251, pages 325–328 (1994)Cite this article

Abstract

Decreased mucociliary transport can occur in patients with type I (IgE-mediated) allergic rhinitis or allergic asthma. This study investigated if the allergic mediators histamine and leukotriene C4 (LTC4) could interfere with ciliary beat frequency (CBF) of in vitro human upper respiratory cilia and eventually result in decreased mucociliary transport. Ciliated epithelium of human adenoid tissue was used in the experiments and CBF was determined using a computer-assisted photoelectric method. Histamine in concentrations of 10−6–10−3 M (n = 12) and LTC4 as 10−9–10−6 M solutions (n = 10) showed no statistically significant dose-dependent effect on CBF in vitro.

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Affiliations

  1. Department of Otorhinolaryngology, University Hospital Utrecht, Room G.05.129, P.O. Box 85500, NL-3508, GA Utrecht, The Netherlands

    P. J. Schuil, J. M. E. van Gelder, M. ten Berge, K. Graamans & E. H. Huizing

Authors
  1. P. J. Schuil
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  2. J. M. E. van Gelder
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  3. M. ten Berge
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  4. K. Graamans
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  5. E. H. Huizing
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Schuil, P.J., van Gelder, J.M.E., ten Berge, M. et al. Histamine and leukotriene C4 effects on in vitro ciliary beat frequency of human upper respiratory cilia. Eur Arch Otorhinolaryngol 251, 325–328 (1994). https://doi.org/10.1007/BF00171538

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  • DOI: https://doi.org/10.1007/BF00171538

Key words

  • Allergic rhinitis
  • Histamine
  • Leukotriene
  • C4
  • Ciliary beat frequency
  • Human upper respiratory cilia