Abstract
Low-frequency acoustic biasing using an intensive phase-shifted, low-frequency masker was studied according to its ability to determine disorders of cochlear micromechanics following noise trauma in the guinea pig as animal model. Statistical analyses proved that this technique allowed electrophysiological differentiation of controls versus groups with different degrees of experimentally induced threshold shifts. To substantiate group differences an intensity of at least 70 dB SPL was required for the 52 Hz masker and the difference in relation to the test-tone intensity had to be ±10 or ±20 dB SPL. The noise-traumatized cochlea could be identified by means of a threshold shift for the 5 μV pseudothreshold, a low modulation span of the compound action potential amplitude (< 25–50μLV frequency dependent), and reduced positive summating potential amplitude with negative non-modulating values within the different measurement phases for 1 and 2kHz stimulation.
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References
Deatherage PH, Henderson D (1967) Auditory sensitization. J Acoust Soc Am 42:438–440
Hoehmann D (1993) Tierexperimentelle Untersuchungen zur Verwendung eines niederfrequenten, phasenverschobenen Maskers in der Innenohrdiagnostik. HNO 41:426–435
Hoehmann D, Georgi KH (1990) The hydropsfinder: an electronic device for the diagnosis of endolymphatic hydrops. Adv Med Technol 16:219–224
Klies JF, Smoorenberg GF (1985) Modulation in the guinea pig round window summating potentials and compound action potentials by low frequency sound. Hear Res 20:15–23
Klies JF, Smoorenberg GF (1988) Cochlea potentials and their modulation by low-frequency sound in early endolymphatic hydrops. Hear Res 32:175–184
Klies JF, Prijs VF, Latour JB, Smoorenberg GF (1988) Modulation of cochlea tuning by low frequency sound. Hear Res 36:163–173
Morizono T, Sikora MR (1984) Neurophysiologic assessment of endolymphatic hydrops. Ann Otol Rhinol Larnygol 93: 225–228
Morizono T, Paparella MM, Lassman F, Sikora MR (1983) Objective diagnosis of endolymphatic hydrops with low frequency biasing. ARO, AAO-HNS Abstract of Research Forum, Anaheim, Calif
Morizono T, Cohen J, Sikora MR (1985) Measurements of action potential thresholds in experimental endolymphatic hydrops. Ann Otol Rhinol Laryngol 94:191–196
Morizono T, Long CH, Hoehmann D (1986) Altered endolymphatic pressure and changes in cochlear function. Ear Res Jpn 17 [Suppl 1]:84–91
Patuzzi R, Johnstone BM, Sellick PM (1984) The alteration of the vibration of the basilar membrane produced by loud sound. Hear Res 13:99–100
Patuzzi R, Sellick PM, Johnstone BM (1984) The modulation of the sensitivity of the mammalian cochlea by low frequency tones. I. Primary afferent activity. Hear Res 13:1–8
Patuzzi R, Sellick PM, Johnstone BM (1984) The modulation of the sensitivity of the mammalian cochlea by low frequency tones. III. Basilar membrane motion. Hear Res 13:19–27
Strehoff D, Dubuo J, Sarantines G (1986) Psychoacoustic measurements of acoustic biasing in normal and impaired human ears. Abstract, VIIth ARO Midwinter Research Meeting
Zwicker E (1977) Masker-period patterns produced by very low frequency masker and their possible relation to basal membrane displacement. J Acoust Soc Am 61:1031–1040
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Hoehmann, D., Muller, S. & Dornhoffer, J.L. Modulation of cochlear responses in the guinea pig by low-frequency, phase-shifted maskers following noise trauma. Eur Arch Otorhinolaryngol 252, 20–25 (1995). https://doi.org/10.1007/BF00171435
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DOI: https://doi.org/10.1007/BF00171435