Abstract
• Background: In this double-blind prospective trial the efficacy of lowering the intraocular pressure of l-moprolol given alone and in combination with dipivefrin was tested. a Methods: Twenty-seven patients with primary open-angle glaucoma or ocular hypertension were randomly assigned to receive twice-daily l-moprolol eye drops or dipivefrin eye drops for 4 weeks; in a second phase of the trial, the combination of the two drugs was administered for 4 weeks. • Results: The results of this study indicated that l-moprolol and dipivefrin had an equivalent effect in lowering the intraocular pressure. The association of the two drugs caused a further reduction of intraocular pressure which was significant only in the group previously treated with dipivefrin alone. • Conclusion: This trial demonstrated that the combination of l-moprolol and dipivefrin is an effective and safe treatment for elevated intraocular pressure.
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Rossetti, L., Barbieri, P., Velati, P. et al. The efficacy of the combination of I-moprolol and dipivefrin in reducing the intraocular pressure in primary open-angle glaucoma or in ocular hypertension. Graefe's Arch Clin Exp Ophthalmol 232, 670–674 (1994). https://doi.org/10.1007/BF00171382
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DOI: https://doi.org/10.1007/BF00171382