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Phase I–II trial of acivicin in adult acute leukemia

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Summary

Six patients with relapsed or refractory acute leukemia were treated with 9 mg/m2 or 11 mg/m2 of acivicin daily for seven days in a phase I–II trial. No responses were attained and further dose escalation was prohibited by neurotoxicity in 2 of 3 patients who received 11 mg/m2/day. Although acivicin appears to have limited potential as a single agent, laboratory evaluation of leukemic blasts in one patient revealed cell cycle (S-phase accumulation) and metabolic effects which suggest that acivicin may be effective as a modulator of other antileukemia agents such as cytosine arabinoside.

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Author notes

  1. John B. Craig

    Present address: Division of Medical Oncology, Universityof Texas, Health Sciences Center, Floyd Curl Drive, 7703, San Antonio, Texas, USA

Authors and Affiliations

  1. Oncology Research Center, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina, USA

    Bayard L. Powell, John B. Craig, Robert L. Capizzi & Frederick Richards II

Authors
  1. Bayard L. Powell
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  2. John B. Craig
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  3. Robert L. Capizzi
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  4. Frederick Richards II
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Powell, B.L., Craig, J.B., Capizzi, R.L. et al. Phase I–II trial of acivicin in adult acute leukemia. Invest New Drugs 6, 41–44 (1988). https://doi.org/10.1007/BF00170778

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  • DOI: https://doi.org/10.1007/BF00170778

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