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Dispersion of retinal pigment epithelial cells from experimental retinal holes

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Abstract

The effects of cryotherapy, transcleral massage, or directed irrigation on exposed retinal pigment epithelial (RPE) cells at the base of an experimental retinal hole were studied in living rabbit eyes. Cryotherpy or massage with or without vitrectomy failed to release RPE cells or result in preretinal membrane formation. Directed irrigation dispersed viable RPE cells into the vitreous and produced cellular precipitates with membranes on the inferior retina, although the membranes tended to regress within 6 weeks after surgery. These results suggest that healthy RPE cells at the base of retinal tears are not easily released into the vitreous and may not contribute to the formation of preretinal membranes found in proliferative vitreoretinopathy.

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Authors and Affiliations

  1. The Eye Research Institute, 02114, Boston, MA, USA

    Salim A. Bishara & Sheldon M. Buzney

  2. Department of Ophthalmology of Harvard Medical School, 02114, Boston, MA, USA

    Sheldon M. Buzney

  3. Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel

    Salim A. Bishara

Authors
  1. Salim A. Bishara
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  2. Sheldon M. Buzney
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This work was supported in part by a grant from MedChem Products, Woburn, Mass

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Bishara, S.A., Buzney, S.M. Dispersion of retinal pigment epithelial cells from experimental retinal holes. Graefe's Arch Clin Exp Ophthalmol 229, 195–199 (1991). https://doi.org/10.1007/BF00170557

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  • DOI: https://doi.org/10.1007/BF00170557

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