Abstract
We describe the long-term results after treatment of 68 eyes showing advanced stages of proliferative vitreoretinopathy with vitrectomy, daunomycin perfusion, and silicone-oil injection. Six reoperations were performed. After 18 months, 73% of the eyes showed no signs of retinal detachment and 89% had a visual acuity of > 20/800. These results are better than those reported in previously published studies. Whether this improvement was due to the daunomycin treatment or to more aggressive surgical techniques such as retinotomies remains to be answered by a randomized trial.
Similar content being viewed by others
References
Ando F (1985) Intraocular hypertension resulting from pupillary block by silicone oil. Am J Ophthalmol 99:87–88
Berman DH, Gombos GM (1989) Proliferative vitreoretinopathy: does low-dose colchicine have an inhibitory effect? A controlled study in humans. Ophthalmic Surg 20:268–272
Blumenkranz M, Hernandez E, Ophir A, Norton EW (1984) 5-Fluorouracil: new applications in complicated retinal detachment for an established antimetabolite. Ophthalmology 91:122–130
Cutler SJ, Ederer F (1958) Maximum utilization of the life table method in analyzing survival. J Chronic Dis 8:699–712
Dimopoulos S, Heimann K (1986) Spätkomplikationen nach Silikonölinjektion. Langzeitbeobachtungen an hundert Fällen. Klin Monatsbl Augenheilkd 189:223–227
Heimann K, Wiedemann P (1989) Cologne classification of Proliferative vitreoretinopathy. In: Heimann K, Wiedemann P (eds) Proliferative vitreoretinopathy. Kaden, Heidelberg, pp 148–149
Körner F, Merz A, Gloor B, Wagner E (1982) Postoperative retinal fibrosis — a controlled clinical study of systemic steroid therapy. Graefe's Arch Clin Exp Ophthalmol 219:268–271
Lewis H, Aaberg TM (1988) Anterior proliferative vitreoretinopathy. Am J Ophthalmol 105:277–284
Lucke K, Laqua H, Foerster MH (1989) Results of silicone oil surgery for proliferative vitreoretinopathy. In: Heimann K, Wiedemann P (eds) Proliferative vitreoretinopathy. Kaden, Heidelberg, pp 212–216
Sell CH, McCuen BW, Landers MB, Machemer R (1987) Longterm results of successful vitrectomy with silicone oil for advanced proliferative vitreoretinopathy. Am J Ophthalmol 103:24–28
Wiedemann P, Lemmen K, Schmiedl R, Heimann K (1987) Intraocular daunomycin for the treatment and prophylaxis of traumatic proliferative vitreoretinopathy. Am J Ophthalmol 104:10–14
Wiedemann P, Lemmen K, Wiedemann R, Moter H, Heimann K (1988) Eine randomisierte Studie zur Behandlung der proliferativen Vitreoretinopathie mit Daunomycin. Fortschr Ophthalmol 85:503–504
Wiedemann P, Evans PY, Wiedemann R, Meyer-Schwickerath R, Heimann K (1989) A fluorescein angiographic study on patients with proliferative vitreoretinopathy treated by vitrectomy and intraocular daunomycin. Int Ophthalmol 13:211–216
Author information
Authors and Affiliations
Additional information
Supported by the Retinovit Foundation
Offprint requests to: K. Heimann
Rights and permissions
About this article
Cite this article
Wiedemann, P., Leinung, C., Hilgers, RD. et al. Daunomycin and silicone oil for the treatment of proliferative vitreoretinopathy. Graefe's Arch Clin Exp Ophthalmol 229, 150–152 (1991). https://doi.org/10.1007/BF00170548
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF00170548