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The acceleration of the extraneuronal efflux of 3H-(±)-isoprenaline induced by high extracellular potassium

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Summary

After loading of the extraneuronal tissues of the perfused rat heart with 3H-isoprenaline the elevation of extracellular K+ concentration (from 2.7 to 15 mmol/1) in the perfusion solution about doubled the rate constant for efflux of the 3H-amine. As this increase was not seen in the presence of 100 μmol/13-O-methyl-isoprenaline (OMI, a potent inhibitor of the uptake2-carrier), it is concluded that the change in the concentration of K+ modulates OMI-sensitive outward transport of 3H-isoprenaline by uptake2, not the diffusional efflux of the amine.

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Abbreviations

MAO:

monoamine oxidase

COMT:

catechol-O-methyltransferase

OMI:

3-O-methyl-isoprenaline

U-0521A:

3,4-dihydroxy-2-methyl propiophenone

References

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Authors and Affiliations

  1. Institut für Pharmakologie and Toxikologie der Universität Wiirzburg, Versbacher Strasse 9, Federal Republic of Germany

    M. Grohmann

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  1. M. Grohmann
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Grohmann, M. The acceleration of the extraneuronal efflux of 3H-(±)-isoprenaline induced by high extracellular potassium. Naunyn-Schmiedeberg's Arch Pharmacol 337, 406–407 (1988). https://doi.org/10.1007/BF00169531

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  • DOI: https://doi.org/10.1007/BF00169531

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