Summary
As yet the antiarrhythmic efficacy of ajmaline with regard to suppressing the induction of sustained ventricular tachycardia after myocardial infarction has not been determined. Therefore, programmed electrical stimulation was performed in 8 conscious, chronically instrumented mongrel dogs 8–20 days after a 4-hour occlusion of the left anterior descending coronary artery. At baseline all animals responded with sustained ventricular tachycardia. Thereafter, ajmaline was administered at two consecutive ix. doses: a bolus of 0.7 mg kg−1 followed by infusion of 2 mg kg−1 h−1 and infusion of 4 mg kg−1 h−1. The induction of sustained ventricular tachycardia was prevented in 2/8 animals by 2 mg kg−1 h−1 ajmaline and in 1/8 animals by 4 mg kg−1 h−1 ajmaline. During sinus rhythm only 4 mg kg−1 h−1 ajmaline significantly increased QRS-duration and intraventricular activation times, but during rapid right ventricular pacing (cycle length = 330 ms) both doses of ajmaline increased QRS duration and intraventricular conduction times. 4 mg kg−1 h−1 ajmaline also increased the cycle length of induced sustained ventricular tachycardia. In 3 animals induction of sustained ventricular tachycardia during infusion of 4 mg kg−1 h−1 ajmaline was achieved by introduction of less extrastimuli than at baseline. Furthermore the coupling intervals of extrastimuli that induced sustained ventricular tachycardia were substantially prolonged by this dose. Inhomogeneity of conduction between left ventricular normal zone and left ventricular infarct zone was significantly increased by 4 mg kg−1 h−1 ajmaline during rapid right ventricular pacing, but not during sinus rhythm.
We conclude that ajmaline has only limited efficacy with regard to the prevention of induction of sustained ventricular tachycardia after myocardial infarction. Drug-induced increases in tachycardia cycle lengths, as observed under the higher dose of ajmaline, were associated with a rate-dependent rise in cardiac electrical instability.
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References
Anastasiou-Napa MI, Anderson JL, Steward JR, Crevey BJ, Yanowitz FG, Lutz JR, Johnson TA (1987) Occurrence of exercise-induced and spontaneous wide complex tachycardia during therapy with flecainide for complex ventricular arrhythmias: a probable proarrhythmic effect. Am Heart J 113:1071–1077
Anderson KP, Walker R, Lux RL, Ershler PR, Menlove R, Williams MR, Krall R, Moddrelle D (1990) Conduction velocity depression and drug-induced ventricular tachyarrhythmias. Effects of lidocaine in the intact canine heart. Circulation 81:1024–1038
Blumenthal MR, Wang HH, Liu LMP (1975) Experimental coronary arterial occlusion and release. Am J Cardiol 36:225–233
Breithardt G, Borggrefe M, Podczeck A, Budde T (1987) Influence of the cycle length of basic drive on induction of sustained ventricular tachycardia associated with coronary artery disease. Am J Cardiol 60:1306–1310
Brembilla Perrot B, Terrier de la Chaise A (1992) Provocation of supraventricular tachycardias by an intravenous class I antiarrhythmic drug. Int J Cardiol 34:189–198
Carson DL, Cardinal R, Savard P, Vasseur C, Nattel S, Lambert C, Nadeau R (1986) Relationship between an arrhythmogenic action of lidocaine and its effects on excitation patterns in acutely ischemic porcine myocardium. J Cardiovasc Pharmacol 8:126–136
Falk RH (1989) Flecainide-induced ventricular tachycardia and fibrillation in patients treated for atrial fibrillation. Ann Int Med 111:107–111
Grenadier E, Alpan G, Keidar S, Weiss D, Marmor A, Palant A (1983) The efficacy of ajmaline in ventricular arrhythmias after failure of lidocaine therapy in the acute phase of myocardial infarction. Angiology 34:204–214
Heistracher P (1971) Mechanisms of action of antifibrillatory drugs. Naunyn-Schmiedeberg's Arch Pharmacol 269:199–211 Proarrhythmic responses during electrophysiologic testing. Am J Cardiol 59:45E-48E
Kimura S, Bassett AL, Gaide MS, Kozlovskis PL, Myerburg RJ (1986) Regional changes in intracellular potassium and sodium activity after healing of experimental myocardial infarction in cats. Circ Res 58:202–208
Köppel C, Wagemann A, Martens F (1989) Pharmacokinetics and antiarrhythmic efficacy of intravenous ajmaline in ventricular arrhythmia of acute onset. Eur J Drug Metab Pharmacokinet 14: 161–167
Krejcy K, Krumpl G, Todt H, Raberger G (1992) Lidocaine has a narrow antiarrhythmic dose range against ventricular arrhythmias induced by programmed electrical stimulation in conscious dogs. Naunyn-Schmiedeberg's Arch Pharmacol 346:213–218
Krumpl G, Todt H, Schunder-Tatzber S, Raberger G (1989a) Holter monitoring in conscious dogs: assessment of arrhythmias occurring in the late reperfusion phase after coronary occlusion. J Pharmacol Methods 22:93–102
Krumpl G, Todt H, Schunder-Tatzber S, Raberger G (1989b) Holter monitoring in conscious dogs: Assessment of arrhythmias occurring during ischemia and in the early reperfusion phase. J Pharmacol Methods 22:77–91
Krumpl G, Todt H, Krejcy K, Raberger G (1990a) Antiarrhythmic efficacy of labetalol as assessed by programmed electrical stimulation. Br J Pharmacol 100:855–861
Krumpl G, Todt H, Schunder-Tatzber S, Raberger G (1990b) Programmed electrical stimulation after myocardial infarction and reperfusion in conscious dogs. J Pharmacol Methods 23:155–169
Kus T, Dubuc M, Lambert C, Shenasa M (1990) Efficacy of propafenone in preventing ventricular tachycardia: inverse correlation with rate-related prolongation of conduction time. J Am Coll Cardiol 16:1229–1237
Lüderitz B, Manz M (1992) Pharmacologic treatment of supraventricular tachycardia: the German experience. Am J Cardiol 70: 66A–73A
Manz M, Luderitz B (1988) Notfalltherapie von ventrikulären Tachykardien: Lidocain versus Ajmalin. Dent Med Wochenschr 113: 1317–1321
Manz M, Mletzko R, Jung W, Luderitz B (1992) Electrophysiological and haemodynamic effects of lidocaine and ajmaline in the management of sustained ventricular tachycardia. Eur Heart J 13:1123–1128
Marchlinski FE, Buxton AE, Josephson ME, Schmitt C (1989) Predicting ventricular tachycardia cycle length after procainamide by assessing cycle length-dependent changes in paced QRS duration. Circulation 79:39–46
Mletzko R, Jung W, Manz M, Luderitz B (1991) Heart-minute volume during persistent ventricular tachycardia: anti-arrhythmia intervention using ajmaline. Z Kardiol 80:459–462
Nesterenko VV, Lastra AA, Rosenshtraukh LV Starmer CF (1992) A proarrhythmic response to sodium channel blockade — modulation of the vulnerable period in guinea pig ventricular myocardium. J Cardiovasc Pharmacol 19:810–820
Patterson E, Gibson JK, Lucchesi BR (1988) Antiarrhythmic and arrhythmogenic actions of methyl lidocaine during the recovery phase after canine myocardial infarction. Pharmacology 36:73–83
Poser RF, Podrid PJ, Lombardi F, Lown B (1985) Aggravation of arrhythmia induced with antiarrhythmic drugs during electrophysiologic testing. Am Heart J 110:9–16
Starmer CF, Lastra AA, Nesterenko VV, Grant AO (1991) Proarrhythmic response to sodium channel blockade. Theoretical model and numerical experiments. Circulation 84:1364–1377
Starmer CF, Lancester AR, Lastra AA, Grant AO (1992) Cardiac instability amplified by use-dependent Na channel blockade. Am J Physiol 262:H1305-H1310
Task Force of the Working Group on Arrhythmias of the European Society of Cardiology (1991) The Sicilian Gambit. Circulation 84:1831–1851
Todt H, Krumpl G, Krejcy K, Schunder-Tatzber S, Raberger G (1990) Programmed electrical stimulation in conscious dogs: electropharmacologic testing of amrinone. Arch Int Pharmacodyn Ther 307:32–48
Todt H, Krumpl G, Krejcy K, Raberger G (1992a) Mode of QT correction for heart rate: Implications for the detection of inhomogeneous repolarization after myocardial infarction. Am Heart J 124: 602–609
Todt H, Krumpl G, Krejcy K, Raberger G (1992b) Mechanism of antiarrhythmic efficacy of propafenone as assessed by programmed electrical stimulation in concious dogs. J Cardiovasc Pharmacol 19:341–348
Wallenstein S, Zucker CL, Fleiss JL (1980) Some statistical methods useful in circulation research. Circ Res 47:1–9
Weirich J, Antoni H (1990) Differential analysis of the frequency-dependent effects of class 1 antiarrhythmic drugs according to periodical ligand binding: Implications for antiarrhythmic and proarrhythmic efficacy. J Cardiovasc Pharmacol 15:998–1009
Yasuhara M, Hashimoto Y, Okumura K, Hori R, Sakurai T, Kawai C (1987) Kinetics of ajmaline disposition and pharmacologic response in beagle dogs. J Pharmacokinet Biopharm 15:39–55
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Todt, H., Krumpl, G., Zojer, N. et al. Effect of ajmaline on sustained ventricular tachycardia induced by programmed electrical stimulation in conscious dogs after myocardial infarction. Naunyn-Schmiedeberg's Arch Pharmacol 348, 290–297 (1993). https://doi.org/10.1007/BF00169158
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DOI: https://doi.org/10.1007/BF00169158