Summary
The purpose of this study was to determine whether or not anemic patients have a higher risk of gentamicin ototoxicity. Using the laboratory rat as an animal model with auditory brain-stem response measurements and surface preparations of the organ of Corti, it could be shown that cochlear damage in anemic rats treated with gentamicin was significantly higher (P< 0.05) than in the nonanemic ones treated with the same dosages of antibiotic. Doses of gentamicin used were 50 mg/kg for 30 days and 40 mg/kg for another 75 days.
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Delb, W., Koch, A. & Federspil, P. Experimental investigations on the influence of anemia on gentamicin ototoxicity. Eur Arch Otorhinolaryngol 248, 342–344 (1991). https://doi.org/10.1007/BF00169026
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DOI: https://doi.org/10.1007/BF00169026