Summary
Using the dog as an animal model, we have tested an implant material composed of purified fibrillar collagen (PFC) and particulate hydroxylapatite (HA) in the mandible and in surrounding tissues. Bone and tissue samples were taken at 2, 4 and 6 months for histological study. After 2 months, the PFC was replaced by fibroconnective host tissues. After 4 months, some small areas of ossification were observed around the HA particles. After 6 months, the fibro-connective tissue was replaced by neo-formed bone in the mandible. PFC was found to increase the interfaces between the HA particles and the host tissues, permitting HA integration into the bone. The PFC/HA implant was also molded when moistened by blood or saline solution and then became mis-shapen by local pressures exerted. These findings show that the implant should preferably be reserved for the restoration of bones not subjected to significant forces or local stresses.
Similar content being viewed by others
References
Barton RT (1980) The use of synthetic implant material in osteoplastic frontal sinusotomy. Laryngoscope 90:47–52
Bell WH, Jacobs JD (1980) Surgical orthodontic correction of maxillary retrusion by LE FORT I osteotomy and Proplast. J Maxillofac Surg 8:84–94
Brown BL, Neel HB III, Kern EB (1979) Implants of Supramid, Proplast, Plasti-Pore and Silastic. Arch Otolaryngol 105 605–609
Chao SY, Poon CK (1987) Histologic study of tissue response to implanted hydroxylapatite in two patients. J Oral Maxillofac Surg 45:359–362
Clark RP, Robertson JH, Shea JJ, Tomoda K (1984) Closure of dural defects with Proplast. Am J Otol 5:179–182
Cooperman LS, Mackinnon V, Bechler G, Pharriss BB (1985) Injectable collagen: a six-year clinical investigation. Aesthetic Plast Surg 9: 145–151
Ferraro JW (1979) Experimental evaluation of ceramic calcium phosphate as a substitute for bone grafts. Plast Reconstruct 63: 634–640
Ford CN (1984) Histologic studies on the fate of soluble collagen injected into canine vocal folds. Laryngoscope 94: 513–518
Ford CN, Gilchrist KW, Bartell TE (1987) Persistence of injectable collagen in the human larynx: a histopathologic study. Laryngoscope 97:724–727
Gongloff RK, Montgomery CK (1985) Experimental study of the use of collagen tubes for implantation of particulate hydroxylapatite. J Oral Maxillofac Surg 43:845–849
Gross BD, Topazian RG (1978) Mucosal grafting over Proplast-augmented edentulous ridges: a pilot study. J Oral Surg 36:948–949
Halstead A, Jones CW, Rawlings RD (1979) A study of the reaction of human tissue to Proplast. J Biomed Mater Res 13:121–134
Hatcher JE, Lemons JK, Matukas VJ, Compton RC (1986) Laboratory animal studies of apatite and collagen biomaterials. J Dent Res 65:347
Holmes RE (1979) Bone regeneration within a coralline hydroxylapatite implant. Plast Reconstruct 63:626–633
Janeke JB, Shea JJ (1976) Proplast implants used in otology and in facial reconstructive surgery. S Afr Med J 50:781–783
Jarcho M (1981) Calcium phosphate ceramics as hard tissue prosthetics. Clin Orthop Relat Res 157:259–278
Kenney EB, Lekovic JC, Ferreira SA, Han TA, Dimitrijevic B, Carranza FA Jr (1986) Bone formation within porous hydroxylapatite implants in human periodontal defects. J Periodonto 157:76–83
Kent JN, Zide MF (1984) Wound healing: bone and biomaterials. Otolaryngol Clin North Am 17:273–319
Kent JN, Westfall RL, Carlton DM (1981) Chin and zygomaticomaxillary augmentation with Proplast. Long-term follow-up. J Oral Surg 39:912–919
Kent JN, Quinn JH, Zide MF, Gerra LR, Boyne PJ (1983) Alveolar ridge augmentation using nonresorbable hydroxylapatite with or without autogenous cancellous bone. J Oral Maxillofac Surg 41:629–642
Mehlisch DR, Taylor TO, Leibold DG, Hiatt R, Waite DE, Waite PD, Laskin MD, Smith ST, Koretz MM (1987) Evaluation of collagen/hydroxylapatite for augmenting deficient alveolar ridges. A preliminary report. J Oral Maxillofac Surg 45:408–413
22.Page DG, Laskin DM (1987) Tissue response at the bone-implant interface in a hydroxylapatite augmented mandibular ridge. J Oral Maxillofac Surg 45:356–358
23.Parkes ML, Merrin ML, Kamer FM (1976) Proplast chin augmentation. Laryngoscope 86:1829–1835
24.Radell BL, Cassingham RJ (1980) Clinical evaluation of Proplast as a periodontal implant material. J Periodonto 151:110–115
Remacle M, Marbaix E (1988) Collagen implants in the human larynx. Pathological examination of two cases. Arch Otorhinolaryngo 1245:203–209
Rothstein SS, Paris DA, Zacek MP (1984) Use of hydroxylapatite for the augmentation of deficient alveolar ridges. J Oral Maxillofac Surg 42:224–230
Schenck NL, Tomlinson MJ (1977) Frontal sinus trauma. Experimental reconstruction with Proplast. Laryngoscope 87: 398–407
Schenck NL, Tomlinson MJ, Ridgley CD (1976) Experimental evaluation of a new implant material in frontal sinus obliteration. Arch Otolaryngol 102:524–528
Van Blitterswijk CA, Kuypers W, Daems WT, Grote JJ (1986) Epithelial reactions to hydroxylapatite. An in vivo and in vitro study. Acta Otolaryngol (Stockh) 101:231–241
Waite PD, Matukas VJ (1986) Zygomatic augmentation with hydroxylapatite. A preliminary report. J Oral Maxillofac Surg 44:349–352
Westfall RL, Homsy CA, Kent JN (1982) A comparison of porous composite PTFE/graphite and PTFE/aluminium oxide facial implants in primates. J Oral Maxillofac Surg 40:771–775
Author information
Authors and Affiliations
Additional information
Offprint requests to: M. Remacle
Rights and permissions
About this article
Cite this article
Remacle, M., Marbaix, E. & Mustin, V. Tissue integration of the collagen-hydroxylapatite implant: histological examination in canine bone and surrounding tissues. Eur Arch Otorhinolaryngol 248, 337–341 (1991). https://doi.org/10.1007/BF00169025
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00169025