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European Journal of Nuclear Medicine

, Volume 20, Issue 2, pp 165–169 | Cite as

An integrated approach to biodistribution radiation absorbed dose estimates

  • Marilyn E. Noz
  • Elissa L. Kramer
  • Gerald Q. MaguireJr.
  • Sharon A. McGee
  • Joseph J. Sanger
Short Communication

Abstract

An integrated approach to existing methods of extracting biodistribution data, pharmacokinetics and radiation absorbed dose estimates from serial scintigraphic images is described. This approach employs a single computer-generated user interface to reformat planar scans into a standard file type, align conjugate (anterior and posterior) images, draw regions of interest (ROIs) over selected organs and lesions and generate count data for anterior and posterior views and calculated geometric means. Using standard correction methods, the fraction injected activity is obtained for all ROIs and total body. This methodology has been applied to the analysis of indium-III-labelled breast-cancer-directed antibodies and technetium-90m-labelled CEA-specific antibody fragments in non-small-cell lung cancer. It is anticipated that this approach will be useful for evaluating the dosimetry of other radiolabelled monoclonal antibodies, as well as other radiopharmaceuticals.

Key words

Integrated approach Biodistribution data Radiation absorbed dose estimates 

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Marilyn E. Noz
    • 1
  • Elissa L. Kramer
    • 1
  • Gerald Q. MaguireJr.
    • 1
    • 2
  • Sharon A. McGee
    • 1
  • Joseph J. Sanger
    • 1
  1. 1.Department of RadiologyNew York UniversityNew YorkUSA
  2. 2.Department of Computer ScienceColumbia University in the City of New YorkNew YorkUSA

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