European Journal of Nuclear Medicine

, Volume 20, Issue 2, pp 146–150 | Cite as

Serial evaluation of left ventricular function by radionuclide ventriculography at rest and during exercise after orthotopic heart transplantation

  • Andreas Hartmann
  • Frank-Dieter Maul
  • Anton Huth
  • Wolfram Burger
  • Gustav Hör
  • Egon Krause
  • Martin Kaltenbach
Original Article


Discrepant results have previously been reported concerning long-term left ventricular function in the human transplanted heart as assessed by radionuclide ventriculography. In this study, radionuclide ventriculograms were obtained at rest and during exercise in 19 patients <6 months, 7–12 months, 13–24 months and >24 months after transplantation. Ejection fraction decreased significantly from <6 months to 13–24 months after transplantation (rest: 69.1%±9.7% to 56.7%±8.3%, P<0.05; exercise: 70.4%±11.3% to 59%±8%, P<0.05). Heart rate increased significantly during exercise after >2 years (90.2±10.5 beats/min to 103.5±15 beats/min, P<0.05) but not within 6 months after transplantation (98.5±12.8 beats/min to 99.07±15.8 beats/min). Left ventricular end-diastolic volume remained unchanged. Peak filling rate at rest decreased significantly from 4.2±0.96 edv/s <6 months after transplantation to 3.3±0.66 edv/s (P<0.05) 13–24 months and 3.3±0.64 edv/s (P<0.05)>24 months after cardiac transplantation. Exercise peak filing rate did not change significantly. It is concluded that radionuclide ventriculography demonstrates a decrease in systolic left ventricular function in the long-term course after cardiac transplantation. A significant increase in exercise peak heart rate may be due to autonomic reinnervation. Differences in the literature concerning left ventricular function may be due to different observation intervals following cardiac transplantation.

Key words

Cardiac transplantation Radionuclide ventriculography Left ventricular function Cardiac allograft rejection 


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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Andreas Hartmann
    • 1
  • Frank-Dieter Maul
    • 2
  • Anton Huth
    • 1
  • Wolfram Burger
    • 1
  • Gustav Hör
    • 2
  • Egon Krause
    • 3
  • Martin Kaltenbach
    • 1
  1. 1.Department of CardiologyJ.W. Goethe University Medical CenterFrankfurt/MainFederal Republic of Germany
  2. 2.Department of Nuclear MedicineJ.W. Goethe University Medical CenterFrankfurt/MainFederal Republic of Germany
  3. 3.Department of Cardiovascular SurgeryJ.W. Goethe University Medical CenterFrankfurt/MainFederal Republic of Germany

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