Summary
Administration of 10–100 μg of histamine into the lateral cerebral ventricle of anaesthetized rats stimulated gastric acid secretion in a dose-dependent manner, while subcutaneous (s. c.) injections of the same doses produced clearly less pronounced increases in the acid output. In vagotomized rats only a marginal response to histamine given into the lateral ventricle was observed. When injected into the third cerebral ventricle the doses of histamine needed for the stimulation of gastric acid secretion were 1–10 μg, the effect being totally abolished by vagotomy. The results indicate that histamine is capable of stimulating gastric acid secretion by a central, vagal-dependent mechanism.
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References
Debas HT (1987) Peripheral regulation of gastric acid secretion. In: Johnson LR (ed) Physiology of the gastrointestinal tract, 2nd edn. Raven Press, New York, pp 931–945
Hernandez DE, Jennes C, Emerick SG (1987) Brain vasoactive intestinal peptide: a potent stimulant of gastric acid secretion. Brain Res 420:129–134
Panula P (1987) Histaminergic mechanisms in the brain. Med Biol 65:9–11
Pellegrino LJ, Pellegrino AS, Cushman AJ (1979) A stereotaxic atlas of the rat brain. Plenum Press, New York
Puurunen J, Huttunen P (1988) Central gastric antisecretory action of adenosine in rats. Eur J Pharmacol 147:59–55
Puurunen J, Karppanen H (1975) Effects of ethanol on gastric acid secretion and gastric mucosal cyclic AMP in the rat. Life Sci 16:1513–1520
Puurunen J, Ruskoaho H (1987) Vagal-dependent stimulation of gastric acid secretion by intracerebroventricularly administered atrial natriuretic peptide in anaesthetized rats. Eur J Pharmacol 141:439–495
Roberts F, Calcutt CR (1983) Histamine and the hypothalamus. Neuroscience 9:721–739
Schwartz J-C, Arrang JM, Garbarg M (1986) Three classes of histamine receptors in brain. Trends Pharmacol Sci 7:24–28
Soll AH, Berglindh T (1987) Physiology of isolated gastric glands and parietal cells. In: Johnson LR (ed) Physiology of the gastrointestinal tract, 2nd edn. Raven Press, New York, pp 883–909
Taché Y (1987) Central nervous system regulation of gastric acid secretion. In: Johnson LR (ed) Physiology of the gastrointestinal tract, 2nd edn. Raven Press, New York, pp 911–930
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Puurunen, J. Centrally applied histamine increases gastric acid secretion in rats. Naunyn-Schmiedeberg's Arch Pharmacol 338, 96–98 (1988). https://doi.org/10.1007/BF00168818
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DOI: https://doi.org/10.1007/BF00168818