Abstract
Effects of angiotensin II on ATP release were evaluated in segments and cultured smooth muscle cells from the guinea-pig taenia coli. In the segments, angiotensin II (0.3–3 μM) elicited release of ATP which was blocked by losartan and SC-52458, non-peptide angiotensin II type-1 receptor (AT1)-antagonists, but not by PD-123319, an AT2-antagonist. In superfused cultured cells, 10μM angiotensin II likewise elicited release of ATP Again the response was blocked by losartan and SC-52458 but not by PD-123319. These findings suggest that angiotensin II releases ATP from the smooth muscles by activation of angiotensin II-, presumably ATE1-, receptors.
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References
Bodin P, Bailey D, Burnstock G (1991) Increased flow induced ATP release from isolated vascular endothelial cells but not smooth muscle cells. Br J Pharmacol 103:1203–1205
Buxton ILD, Walther J, Westfall DP (1990) α-Adrenergic receptor-stimulated release of ATP from cardiac endothelial cells in primary culture. Ann NY Acad Sci 603:503–506
Driessen B, Starke K (1994) Modulation of neuronal noradrenaline and ATP release by angiotensin II and prostaglandin E2 in guinea-pig vas deferens. Naunyn-Schmiedeberg's Arch Pharmacol 350: 618–625
Ellis JL, Bunstock G (1989) Angiotensin neuromodulation of adrenergic and purinergic co-transmission in the guinea-pig vas deferens. Br J Pharmacol 97:1157–1164
Evans RJ, Darkach V, Suprenant A (1992) ATP mediates fast synaptic transmission in mammalian neurons. Nature 357:503–505
Fredholm BB, Hedqvist P (1978) Release of 3H-purines from 3H-adenine labelled rabbit kidney following sympathetic nerve stimulation and its inhibition by α-adrenoceptor blockade. Br J Pharmacol 64:239–245
Katsuragi T, Tokunaga T, Miyamoto K, Kuratomi L, Furukawa T (1988) Norepinephrine and adenosine triphosphate release in different ratio from guinea-pig vas deferens by high potassium chloride, ouabain and monensin. J Pharmacol Exp Ther 247:302–308
Katsuragi T, Tokunaga T, Usune S, Furukawa T (1990) A possible coupling of postjunctional ATP release and transmitters' receptor stimulation in smooth muscles. Life Sci 46:1301–1307
Katsuragi T, Tokunaga T, Ogawa S, Soejima O, Sato C, Furukawa T (1991) Existence of ATP-evoked ATP release system in smooth muscles. J Pharmacol Exp Ther 259:513–518
Katsuragi T, Soejima O, Tokunaga T, Furukawa T (1992) Evidence for postjunctional release of ATP evoked by stimulation of muscarinic receptors in ileal longitudinal muscles of guinea pig. J Pharmacol Exp Ther 260:1309–1313
Katsuragi T, Matsuo K, Sato C, Honda K, Kamiya H, Furukawa T (1996) Non-neuronal release of ATP and inositol 1,4,5-trisphosphate accumulation evoked by P2- and M-receptor stimulation in guinea pig ileal segments. J Pharmacol Exp Ther 277:747–752
Kügelgen I von, Starke K (1991) Release of noradrenaline and ATP by electrical stimulation and nicotine in guinea-pig vas deferens. Naunyn-Schmiedeberg's Arch Pharmacol 344:419–429
Kügelgen I von, Allgaier C, Schobert A, Starke K (1994) Co-release of noradrenaline and ATP from cultured sympathetic neurons. Neuroscience 61:199–202
Ohta K, Kim S, Hamaguchi A, Yukimura T, Miura K, Takaori K, Iwao H (1994) Role of angiotensin II in extracellular matrix and transforming growth factor-β1 expression in hypertensive rat. Eur J Pharmacol 269:115–119
Satchell DG, Maguire MH (1975) Inhibitory effects of adenine nucleotide analogs on the isolated guinea-pig taenia coli. J Pharmacol Exp Ther 195:540–548
Smith RD, Chin AT, Wong PC, Herblin WF, Timmermans PBMWM (1992) Pharmacology of nonpeptide angiotensin II receptor antagonists. Annu Rev Pharmacol Toxicol 32:135–165
Timmermans PBMWM, Wong PC, Chin AT, Herblin WE, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JAM, Smith RD (1993) Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 45:205–251
Usune S, Furukawa T (1996) Effects of SC-52458, a new nonpeptide angiotensin II receptor antagonist, on increase in cytoplasmic Ca2+ concentration and contraction induced by angiotensin II and K+-depolarization in guinea-pig taenia coli. Gen Pharmacol (in press)
Westfall DP, Stitzel RE, Rowe JN (1978) The postjunctional effects and neuronal release of purine compounds in the guinea-pig vas deferens. Eur J Pharmacol 50:27–28
White TD, Downie JW, Leslie RA (1985) Characteristics of K+- and veratridine-induced release of ATP from synaptosomes prepared from dorsal and ventral spinal cord. Brain Res 334:372–374
Yang S, Cheek DJ, Westfall DP, Buxton IL (1994) Purinergic axis in cardiac blood vessels: Agonist-mediated release of ATP from cardiac endothelial cells. Circ Res 74:401–407
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Katsuragi, T., Tamesue, S., Sato, Y. et al. ATP release by angiotensin II from segments and cultured smooth muscle cells of guinea-pig taenia coil. Naunyn-Schmiedeberg's Arch Pharmacol 354, 796–799 (1996). https://doi.org/10.1007/BF00166908
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DOI: https://doi.org/10.1007/BF00166908