Summary
The distribution of opiate binding sites was studied in sections of rat lumbar spinal cord under conditions selective for μ, σ and κ receptors. While the levels of μ binding sites were highest in the substantia gelatinosa, elevated levels were also observed in laminae III, IV, V and VIII. In contrast, σ binding was notable only in lamina I. The levels of typical κ sites were low, and were concentrated in the substantia gelatinosa. An additional, atypical site was detected using 3H-diprenorphine in the presence of μ, σ and κ receptor blocking agents, and this site was also concentrated in the substantia gelatinosa.
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Morris, B.J., Herz, A. Distinct distribution of opioid receptor types in rat lumbar spinal cord. Naunyn-Schmiedeberg's Arch Pharmacol 336, 240–243 (1987). https://doi.org/10.1007/BF00165811
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DOI: https://doi.org/10.1007/BF00165811