Summary
Pertussis toxin, which specifically inactivates guanine nucleotide-binding proteins (N-proteins) involved in the signal transduction in various receptor systems, did not influence the positive inotropic effect of the alpha1-adrenoceptor agonist phenylephrine in rat isolated left auricles. This indicates that the alpha1-adrenoceptor-mediated positive inotropic effect does not involve a pertussis toxin-sensitive N-protein.
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Böhm, M., Schmitz, W. & Scholz, H. Evidence against a role of a pertussis toxin-sensitive guanine nucleotide-binding protein in the alpha1-adrenoceptor-mediated positive inotropic effect in the heart. Naunyn-Schmiedeberg's Arch Pharmacol 335, 476–479 (1987). https://doi.org/10.1007/BF00165566
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DOI: https://doi.org/10.1007/BF00165566