Abstract
A case is reported of a 36 y/o man treated with radiation therapy for cervical cord ependymoma who developed malignant fibrous histiocytoma of the cervical spine 15 years later. Pathology revealed the sarcoma adjacent to the recurrent ependymoma. Post-radiation sarcomas following treatment of central nervous system malignancies is discussed.
Similar content being viewed by others
References
Shands HC, Finsinger JE, Cobb et al.: Psychological mechanisms in patients with cancer. Cancer 4: 1159–1170, 1951
Pinkston John A, M.D. and Sekine, Ichro. Postirradiation sarcoma (malignant fibrous histiocytoma following cervix cancer. Cancer 49: 434–438, 1982
Coleman N, Tucker MA. In: DeVita (ed) Principle and Practices of Oncology, 3rd Ed.: 2181–2188, 1559 Philadelphia, JB Lippincott, 1989
Pinksterston J, Sekiknel John A: Post irradiation sarcoma (malignant fibrous histiocytoma) for cervical cancer. Cancer 49: 4334–4438, 1982
Case S: Radiation induced cancer in man. J Radiology 30: 393–402, 1957
Amine ARC, Sugar OJ: Supracellar osteogenic sarcoma following radiation for pituitary adenoma. J Neurosurg 44: 88–91, 1976
Chang CH, Pool L: The radiotherapy of pituitary chromophone adenoma. An evaluation of indication, technique, and result. Radiology 89: 1005–1016, 1967
Goldberg MB, Sheline GE, Malamud N: Malignant intracranial neoplasm following radiation therapy for acromegaly. Radiology 80: 465–470, 1963
Greenhouse AM: Pituitary sarcoma — a possible consequence of radiation. JAMA 190: 269–273, 1974
Ahmad K, Fayos Juan V: Pituitary fibrosarcoma secondary to radiation therapy. Cancer 42: 107–110, 1978
Raffee C, Edwards MS, David RL et al.: Post irradiation glioma. Case Report. J Neurosurg 62: 300
Malone M, Lumlbey H, Erdohazi M: Astrocytoma as a second malignancy in patients with acute lymphoblastic lymphoma. Cancer 577: 979, 1986
Sogg RI, Donaldson SS, York CH: Malignant astrocytoma following radiotherapy of a craniopharyngioma. J Neurosurg 48: 622, 1978
Rubenstein AB, Shalit MN, Cohen M et al.: Radiation-induced cerebral meningioma. A recognizable entity. J Neurosurg 61: 966, 1984
Spallone A, Gagliardi FM, Vagnazzi R: Intracranial meningiomas related to external cranial irradiation. Surg Neurology 12: 153, 1979
Cahan WG, Woodward HA, Higgenbotham NL, Stewart FW, Coley BL: Sarcoma arising in irradiated bone. Report of 11 cases. Cancer 1: 3–29, 1948
Kim RC, Kim Choe W BHCMOI: Malignant fibrous histiocytoma arising within a site of prior laminectomy for withdrawal spinal lipoma. Abstracts J Neuropathol Exp Neuro Vol 49, May, 1990
Halperin Joshua, Kopolovic Juri, Catane Raphael: Malignant fibrous histiocytoma developing irradiated sacral chordoma. Cancer 53: 2661–2662, 1984
Weiner M, Sedis, Wolff M, Dick H: Adjuvant chemotherapy of malignant fibrous histiocytoma of bone. Proc Am Soc Clin Oncol 22: 408, 1981
Urban Christian, Rosen Gerald, Huvos Andrew G: Chemotherapy of malignant fibrous histiocytoma of bone. A report of five cases. Cancer 51: 795–802, 1983
Leite C, Goodwin JW, Sinkovics JG, Baker LH, Benjamin R: Chemotherapy of malignant fibrous histiocytoma: A Southwest Oncology Group report. Cancer 40: 2010–2014, 1977
Basset WB, Weiss RB: Prolonged complete remission in malignant fibrous histiocytoma with chemotherapy. Cancer Treat Rep 62: 1405–1406, 1978
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nadeem, S.Q., Feun, L.G., Bruce-Gregorios, J.H. et al. Post radiation sarcoma (malignant fibrous histiocytoma) of the cervical spine following ependymoma (a case report). J Neuro-Oncol 11, 263–268 (1991). https://doi.org/10.1007/BF00165536
Issue Date:
DOI: https://doi.org/10.1007/BF00165536