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Problemes d'autoimmunite dans les uveites

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Résumé

L'autoimmunité est une explication classique de la pathogénie de l'ophtalmie sympathique et de la phacoanaphylaxie. Les aspects histopathologiques, la reproduction expérimentale de ces affections s'accordent avec cette interprétation. La nature des autoantigènes et leur répartition dans l'organisme, leur caractère naturel ou acquis sont des problèmes discutés. On démontre la présence d'anticorps sériques et d'une hypersensibilité retardée chez les malades atteints de ces uvéites, ainsi que dans d'autres affections de l'uvée et du cristallin.

Summary

Autoimmunity is a common explanation of the pathogeny of sympathetic ophthalmitis and phacoanaphylaxis. The histopathological aspects, the experimental reproduction of these diseases agree with this interpretation. The nature of the antigens and their distribution in the body, their natural or acquired character are discussed. The presence of humoral antibodies and of an hypersensitivity of the delayed type are shown in patients suffering from these uveites and other uveal and lens diseases.

Zusammenfassung

Die Autoimmunität ist eine klassische Erklärung der Pathogenese der sympathischen Ophthalmie und der Phacoanaphylaxie. Die histopathologischen Aspekte und die experimentelle Reproduktion dieser Krankheiten stimmen mit dieser Erklärung überein. Die Natur der Autoantigene und ihre Verteilung im Körper, ihr natürlicher oder erworbener Charakter werden diskutiert. Man kann die Anwesenheit von Serumantikörpern und von Überempfindlichkeitsreaktionen vom Tuberkulintyp bei Kranken mit dieser Uveitis nachweisen, ebenso bei anderen Affektionen der Uvea oder der Linse.

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  1. Paris, France

    J. P. Faure & G. Offret

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  1. J. P. Faure
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  2. G. Offret
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Clinique ophtalmologique de l'Hôtel-Dieu, Paris.

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Faure, J.P., Offret, G. Problemes d'autoimmunite dans les uveites. Doc Ophthalmol 20, 333–353 (1966). https://doi.org/10.1007/BF00165426

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