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Blood pressure and gastric motor responses to bradykinin and hydrochloric acid injected into somatic or visceral tissues

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Summary

Both visceral and somatic nociceptive stimuli elicit reflex changes in blood pressure and gastric motor activity, but the exact type of response varies with the type of nociceptive stimulus and its site of application. Therefore, the present study compared the effects of visceral (i. p. or i. a.) and somatic (s. c.) administration of bradykinin and HCl on both mean arterial blood pressure (MAP) and intragastric pressure in anaesthetized rats. The nervous pathways mediating these responses were investigated by surgical or pharmacological inhibition of the possible reflex arcs.

Bradykinin (i. a. — into the aortic arch, i. p., and s. c.), and HCI (i. p. and s. c.), elicited a fall in MAP followed by a transient increase. Intragastric pressure decreased in response to administration of these chemicals. Acute coeliac ganglionectomy reduced the gastric relaxations in response to both bradykinin and HCl, whereas vagotomy reduced only the gastric relaxations induced by HCl. Neither lesion influenced the changes in MAP after either chemical. Ablation of small diameter afferents by capsaicin or chemical sympathectomy by guanethidine reduced the changes in MAP after both chemicals, except that which occurred after i. a. injection of bradykinin. The secondary increase in MAP after i. a. and i. p. administration of algesics was increased after guanethidine. Both pretreatments reduced gastric relaxations in response to either chemical. Pretreatment of the rats with the bradykinin antagonist Hoe-140 reduced the responses to bradykinin but not to HCl.

The results show that both visceral and somatic administration of painful chemicals elicit reflex falls in00 MAP and intragastric pressure. In general, the responses are stronger after “visceral” than after “somatic” administration. Both the splanchnic and vagal pathways seem to be involved in mediating the gastric motor responses. However, the effects of different algesics are not necessarily mediated by the same mechanisms.

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References

  • Amann R, Lembeck F (1986) Capsaicin-sensitive afferent neurons from peripheral glucose receptors mediate the insulin-induced increase in adrenaline secretion. Naunyn-Schmiedeberg's Arch Pharmacol 334:71–76

    Google Scholar 

  • Beck PW, Handwerker HO (1974) Bradykinin and serotonin effects on various types of cutaneous nerve fibres. Pflügers Arch 347:209–222

    Google Scholar 

  • Burch RM, Farmer SG, Steranka LR (1990) Bradykinin receptor antagonists. Med Res Rev 10:237–269

    Google Scholar 

  • Cervero F, McRitchie HA (1982a) Neonatal capsaicin does not affect unmyelinated efferent fibers of the autonomic nervous system: functional evidence. Brain Res 239:283–288

    Google Scholar 

  • Cervero F, McRitchie HA (1982b) Effects of neonatal administration of capsaicin on several nociceptive systems of the rat. In: Bonica JJ (ed) Advances in pain research and therapy, vol 5. Raven Press, New York, pp 87–94

    Google Scholar 

  • Dickerson GD, Engle RJ, Guzman F, Rodgers DW, Lim RKS (1965) The intraperitoneal bradykinin-evoked pain test for analgesia. Life Sci 4:2063–2069

    Google Scholar 

  • Donnerer J (1988) Reflex activation of the adrenal medulla during hypoglycemia and circulatory dysregulations is regulated by capsaicin-sensitive afferents. Naunyn-Schmiedeberg's Arch Pharmacol 338:282–286

    Google Scholar 

  • Donnerer J, Schuligoi R, Lembeck F (1989) Influence of capsaicin-induced denervation on neurogenic and Immoral control of arterial pressure. Naunyn-Schmiedeberg's Arch Pharmacol 340:740–743

    Google Scholar 

  • Gamse R, Leeman SE, Holzer P, Lembeck F (1981) Differential effects of capsaicin on the content of somatostatin, substance P, and neurotensin in the nervous system of the rat. Naunyn-Schmiedeberg's Arch Pharmacol 317:140–148

    Google Scholar 

  • Glise H, Abrahamsson H (1980) Spine-vagal nonadrenergic inhibition of gastric motility elicited by abdominal nociceptive stimulation in the cat. Scand J Gastroenterol 15:665–672

    Google Scholar 

  • Hallerbäck B, Glise H, Sjögvist A (1987) Reflex sympathetic inhibition of colonic motility in the cat. Scand J Gastroenterol 22:141–148

    Google Scholar 

  • Higashi H, Ueda N, Nishi S, Gallagher JP, Shinnick-Gallagher P (1982) Chemoreceptors for serotonin (5-HT), bradykinin (BK), histamine (H) and γ-aminobutyric acid (GABA) on rabbit visceral afferent neurons. Brain Res Bull 8:23–32

    Google Scholar 

  • Holzer-Petsche U, Lembeck F, Seitz H (1987) Contractile effects of substance P and neurokinin A on the rat stomach in vivo and in vitro. Br J Pharmacol 90:273–279

    Google Scholar 

  • Jänig W, Morrison JFB (1986) Functional properties of spinal visceral afferents supplying abdominal and pelvic organs, with special emphasis on visceral nociception. In: Cervero F, Morrison JFB (eds) Visceral sensation (Progress in brain research, vol 67). Elsevier Science Publishers BV, Amsterdam (North Holland), pp 87–114

    Google Scholar 

  • Johnson AR (1979) ffects of kinins on organ systems. In: Erdös EG (ed) Bradykinin, kallidin and kallikrein. Handbook of Experimental Pharmacology, vol 25/Suppl. Springer, Berlin, pp 357–399

    Google Scholar 

  • Juan H, Lembeck F (1974) Action of peptides and other algesic agents on paravascular pain receptors of the isolated perfused rabbit ear. Naunyn-Schmiedeberg's Arch Pharmacol 283:151–164

    Google Scholar 

  • Kametani H, Sato A, Sato Y, Simpson A (1979) Neural mechanisms of reflex facilitation and inhibition of gastric motility to stimulation of various skin areas in rats. J Physiol (Lond) 294:407–418

    Google Scholar 

  • Kanaka R, Schaible HG, Schmidt RF (1985) Activation of fine articular afferent units by bradykinin. Brain Res 327:81–90

    Google Scholar 

  • Kirchgessner AL, Gershon MD (1989) Identification of vagal efferent fibers and putative target neurons in the enteric nervous system of the rat. J Comp Neurol 285:38–53

    Google Scholar 

  • Lembeck F, Donnerer J (1983) Reflex fall in blood pressure mediated by capsaicin-sensitive afferent fibers of the rat splanchnic nerve. Naunyn-Schmiedeberg's Arch Pharmacol 322:286–289

    Google Scholar 

  • Lembeck F, Skofitsch G (1982) Visceral pain reflex after treatment with capsaicin and morphine. Naunyn-Schmiedeberg's Arch Pharmacol 321:116–122

    Google Scholar 

  • Lembeck F, Griesbacher T, Eckhardt M, Henke S, Breipohl G, Knolle J (1991) New, long-acting, potent bradykinin antagonists. Br J Pharmacol 102:297–304

    Google Scholar 

  • Lindahl O (1962) Pain: a chemical explanation. Acta Rheumatol Scand 8:161–169

    Google Scholar 

  • Miele E, De Natale G (1966) Modification by guanethidine and nethalide of the pressor effects of bradykinin in the rat. Arch Int Pharmacodyn 164:56–66

    Google Scholar 

  • Mizutani M, Neya T, Nakayama S (1990) Capsaicin-sensitive afferents activate a sympathetic intestinointestinal inhibitory reflex in dogs. J Physiol (Lond) 425:133–144

    Google Scholar 

  • Ordway GA, Longhurst JC (1983) Cardiovascular reflexes arising from the gallbladder of the cat. Effects of capsaicin, bradykinin, and distension. Circ Res 52:26–35

    Google Scholar 

  • Ordway GA, Longhurst JC, Mitchell JH (1983) Stimulation of pancreatic afferents reflexly activates the cardiovascular system in cats. Am J Physiol 245:R820-R826

    Google Scholar 

  • Ordway GA, Boheler KR, Longhurst JC (1988) Stimulating intestinal afferents reflexly activates cardiovascular system in cats. Am J Physiol 254:H354-H360

    Google Scholar 

  • Radhakrishnan V, Shankar N, Gogia M, Sharma KN (1985) Cardiorespiratory changes following chemical applications to gut serosa. J Auton Nerv Syst 14:363–375

    Google Scholar 

  • Sjögvist A, Hallerbäck B, Glise H (1985) Reflex adrenergic inhibition of colonic motility in anesthetized rat caused by nociceptive stimuli of peritoneum. Dig Dis Sci 30:749–754

    Google Scholar 

  • Szolcsányi J (1987) Selective responsiveness of polymodal nociceptors of the rabbit ear to capsaicin, bradykinin and ultra-violet irradiation. J Physiol (Lond) 388:9–23

    Google Scholar 

  • Terragno NA, Terragno A (1979) Release of vasoactive substances by kinins. In: Erdös EG (ed) Bradykinin, kallidin and kallikrein. Handbook of Experimental Pharmacology, vol 25/Suppl. Springer, Berlin Heidelberg New York, pp 401–426

    Google Scholar 

  • Waldrop TG, Ordway GA (1986) Role of prostaglandins in initiating cardiovascular reflexes originating from the pancreas and the gall bladder. Cardiovasc Res 20:312–316

    Google Scholar 

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  1. Institut für Experimentelle und Klinische Pharmakologie, Karl-Franzens-Universität Graz, Universitätsplatz 4, A-8010, Graz, Austria

    Ulrike Hotzer-Petsche

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  1. Ulrike Hotzer-Petsche
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Hotzer-Petsche, U. Blood pressure and gastric motor responses to bradykinin and hydrochloric acid injected into somatic or visceral tissues. Naunyn-Schmiedeberg's Arch Pharmacol 346, 219–225 (1992). https://doi.org/10.1007/BF00165305

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  • DOI: https://doi.org/10.1007/BF00165305

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