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Circadian rhythm of the B max of [3H]-imipramine binding in rabbit platelets

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Summary

[3H]-imipramine binding was measured in rabbit blood platelet membranes on a 24 h cycle. Animals were kept on a 14 h light (L) 10 h dark (D) schedule, and blood samples were collected at L + 2, L + 8, D + 2, D + 8 and L − 2 h on a following cycle. Significant differences were found for Bmax values of [3H]-imipramine binding, with highest values during the dark phase and lowest during the light phase. No significant differences were found in K d values. These results suggest the existence of a circadian rhythm for the Bmax of [3H]-imipramine binding in blood platelets.

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Authors and Affiliations

  1. Department of Biology, Laboratoires d'Etudes et de Recherches Synthélabo (LERS), 58, rue de la Glacière, F-75013, Paris, France

    Anne Marie Galzin & Salomon Z. Langer

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  1. Anne Marie Galzin
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  2. Salomon Z. Langer
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Galzin, A.M., Langer, S.Z. Circadian rhythm of the B max of [3H]-imipramine binding in rabbit platelets. Naunyn-Schmiedeberg's Arch Pharmacol 336, 464–466 (1987). https://doi.org/10.1007/BF00164884

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  • DOI: https://doi.org/10.1007/BF00164884

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