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Clinical and physical measurements of the cataractous lens

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Abstract

In connection with the clinical trial of an anti-cataract drug (Bendazac lysine) a number of examination methods were used to assess the progress of the cataract: slitlamp examination, visual acuity determination, and the measurement of the contrast sensitivity, light scatter in the eye and the autofluorescence and transmission of the lens. In this article the measurements of 43 patients (43 eyes) are presented, taken at the time that medication was started. In this way we can get an impression of the value of these measurements for the study of cateractous lenses. The contrast sensitivity of the cataractous eye is lowered for all spatial frequencies as compared with the normal population. Light scatter is greatly increased. The autofluorescent profile of the lens with nuclear cateract differs markedly from that of the lens with cortical cataract.

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References

  1. Neuman AC, McCarty GR, Steedle TO, et al. The relationship between indoor and outdoor Snellen visual acuity in cataract patients. J Cataract Refract Surg 1988; 14: 35–39.

    Google Scholar 

  2. Neuman AC, McCarty GR, Steedle TO, et al. The relationship between cataract type and glare disability as measured by the Miller-Nadler glare tester. J. Cataract Refract Surg 1988; 14: 40–45.

    Google Scholar 

  3. Paulsson LE, Sjöstrand J. Contrast sensitivity in the presence of a glare light. Invest Ophthalmol Vis Sci 1980; 19: 401–6.

    Google Scholar 

  4. Abrahamsson M, Sjöstrand J. Impairment of contrast sensitivity function (CSF) as a measure of disability glare. Invest Ophthalmol Vis Sci 1986; 27: 1131–36.

    Google Scholar 

  5. van den Berg TJTP. Importance of pathological intraocular light scatter for visual disability. Doc Ophthalmol 1986; 61: 327–33.

    Google Scholar 

  6. Koch DD. Glare and contrast sensitivity testing in cataract patients. J Cataract Refract Surg 1989; 15: 158–64.

    Google Scholar 

  7. Sjöstrand J, Abrahamsson M, Hard AL. Glare disability as a cause of deterioration of vision in cataract patients. Acta Ophthalmol 1987; 65 Suppl.182: 103–6.

    Google Scholar 

  8. Bettelheim FA, Chylack LT. Light scattering of whole excised human cataractous lenses. Exp Eye Res 1985; 41: 19–30.

    Google Scholar 

  9. van den Berg TJTP, de Waard PWT, IJspeert JK, de Jong PTVM. Intraocular light scattering assessed quantitatively in age-related cataract. Invest Ophthalmol Vis Sci (Suppl) 1989; 30: 499.

    Google Scholar 

  10. Witmer FK, van den Brom HJB, Kooijman AC, Blanksma LJ. Intra-ocular light scatter in pseudophakia. Doc Ophthalmol 1989; 72: 335–40.

    Google Scholar 

  11. Bessems GJH, Keizer E, Wollensak J, Hoenders HJ. Non-tryptophan fluorescence of crystallins from normal and cataractous human lenses. Invest Ophthalmol Vis Sci 1987; 28: 1157–63.

    Google Scholar 

  12. Jacobs R, Krohn DL. Fluorescence intensity profile of the human lens sections. Inv Ophthalmol Vis Sci 1981; 20: 117–20.

    Google Scholar 

  13. Lerman S, Hockwin O, Dragomirescu V. In vivo lens fluorescence photography. Ophthalmic Res 1981; 13: 224–28.

    Google Scholar 

  14. Lerman S. Human lens fluorescence aging index. Lens Research 1988; 5; 23–31.

    Google Scholar 

  15. Lichter PR. Interpreting tests: Implications for cataract surgery (editorial). Ophthalmology 1988; 95: 1–2.

    Google Scholar 

  16. Koch HR, Ebertz KH, Hockwin O. Konservative Katarakttherapie in Klinik und Experiment. Doc Ophtalmol 1973; 35: 91–286.

    Google Scholar 

  17. Kador PF. Overview of the current attempts toward the medical treatment of cataract. Ophthalmology 1983; 90: 352–64.

    Google Scholar 

  18. Hockwin O. Welches sind die Beeinflussungsmöglichkeiten der Kataractentstehung aufgrund heutiger biochemischer Kenntnisse? Klin Mbl Augenheilk 1985; 186: 355–61.

    Google Scholar 

  19. Bron AJ, Brown NAP, Sparrow JM, Shun-Shin GA. Medical treatment of cataract. Eye 1987; 1: 542–50.

    Google Scholar 

  20. Kupfer C. Four main causes of blindness: cataract. In: The International Agency for the Prevention of Blindness, Kupfer C (ed). World Blindness and its Prevention, Vol 3. Oxford: University Press, 1988; 23–25.

    Google Scholar 

  21. Ferris FL, Kassoff A, Bresnick GH, Bailey I. New visual acuity charts for clinical research. Am J Ophthalmol 1982; 94: 91–96.

    Google Scholar 

  22. Arden GB. The importance of measuring contrast sensitivity in cases of visual disturbance. Br J Ophthalmol 1978; 62: 198–209.

    Google Scholar 

  23. van Best JA, Tjin A Tsoi EWSJ, Boot JP, Oosterhuis JA. In vivo assessment of lens transmission for blue-green light by autofluorescence measurement. Ophthalmic Res 1985; 17: 90–95.

    Google Scholar 

  24. Spector A, Debdutta R, Stauffer J. Isolation and characterisation of an age-dependent polypeptide from human lens with non-tryptophan fluorescence. Exp Eye Res 1975; 21: 9–24.

    Google Scholar 

  25. Liang JN, Pelletier MR, Chylack Jr LT. Front surface fluorometric study of lens insoluble proteins. Curr Eye Res 1988; 7: 61–67.

    Google Scholar 

  26. Bleeker JC, van Best JA, Vrij L, van der Velde EA, Oosterhuis JA. Autofluorescence of the lens in diabetic and healthy subjects by fluorophotometry. Invest Ophthalmol Vis Sci 1986; 27: 791–94.

    Google Scholar 

  27. Occhipinti JR, Mosier MA, Burstein NL. Autofluorescence and light transmission in the aging crystalline lens. Ophthalmologica 1986; 192: 203–9.

    Google Scholar 

  28. Owsley C, Gardner T, Seculer R, Lieberman H. Role of the crystalline lens in the spatial vision loss of the elderly. Invest Ophthalmol Vis Sci 1985; 26: 1165–70.

    Google Scholar 

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Van Den Brom, H.J.B., Kooijman, A.C. & Blanksma, L.J. Clinical and physical measurements of the cataractous lens. Doc Ophthalmol 75, 247–258 (1990). https://doi.org/10.1007/BF00164838

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