Abstract
Transplants from the same C3H mouse mammary tumour have been used for radiobiological experiments with curative intent for more than 8 years. During that time, the rate of metastasis to the lungs has varied between 0 and 63% and an explanation has been sought for this change. The results of immunological assays showed no obvious pattern. An inverse relationship was found between tumour latency and metastasis.
Similar content being viewed by others
References
NiasAHW, Chamberlain SM and Abdelaal AS, 1980, The serially transplanted C3H mouse tumour as a clinically relevant model system. British Journal of Cancer, 41, Suppl IV, 157.
Walker A, McCallum HM, Wheldon TE, Nias AHW and Abdelaal AS, 1978, Promotion of metastasis of C3H mouse mammary carcinoma by local hyperthermia. British Journal of Cancer, 38, 561–563.
Walker A, 1982, Tumour response and dissemination following hyperthermia. PhD Thesis, University of Glasgow.
Penhaligon M, Anthoons J, Pilkington D, Wolstencroft RA, Bates T and Nias AHW, 1984, Antimetastatic effect of cimetidine on mice bearing a C3H mouse mammary adenocarcinoma: survival and lymphocyte function studies. Clinical and Experimental Metastasis, 2, 37–53.
Nias AHW, 1967, Radiobiological aspects of pre-operative irradiation. British Journal of Radiology, 40, 166–169.
Abdelaal AS and Nias AHW, 1979, Regression, recurrence and cure in an irradiated mouse tumour. Journal of the Royal Society of Medicine, 72, 100–105.
Sheldon PW, Begg AC, Fowler JF and Lansley IF, 1974, The incidence of lung metastases in C3H mice after treatment of implanted solid tumours with X-rays or surgery. British Journal of Cancer, 30, 342.
Abdelaal AS, 1979, Biological properties and response to X-rays of a multiple generation C3H mammary carcinoma. PhD Thesis, University of Glasgow.
Tozer GM, 1982, Hyperbaric oxygen and tumour response to radiation in the C3H mouse. PhD Thesis, University of London.
Penhaligon M, Laverick M and Nias AHW, 1982, Combination CHIP-X-ray treatment of the C3H mammary adenocarcinoma. British Journal of Cancer, 46, 498.
Abdelaal AS, Chamberlain SM, Nias AHW and Walker A, 1978, Metastases and immunological studies in C3H mice after hyperthermia. British Journal of Radiology, 51, 937 (Abstract).
Ketcham AS, Wexler H and Mantel N, 1959, The effect of removal of a “primary” tumor on the development of spontaneous metastases. I. Develop ment of a standardized experimental technic. Cancer Research, 19, 940–944.
Suit HD, Sedlaceck RS and Gillette EL, 1970, Examination for a correlation between probabilities of development of distant metastasis and of local recurrence. Radiology, 95, 189–194.
Hill RP and Bush RS, 1969, A lung-colony assay to determine the radiosensitivity of the cells of a solid tumour. International Journal of Radiation Biology, 15, 435–444.
Stackpole CW, 1981, Distinct lung-colonizing and lung-metastasizing cell populations in B16 mouse melanoma. Nature, 289, 798–800.
Weiss L, Mayhew E, Glaves Rapp D and Holmes JC, 1982, Metastatic inefficiency in mice bearing B16 melanomas. British Journal of Cancer, 45, 44–54.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nias, A.H.W. Rate of metastasis from C3H mouse mammary tumours. Clin Exp Metast 10, 13–17 (1992). https://doi.org/10.1007/BF00163571
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00163571