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Genetics of B-cell neoplasia

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Abstract

Somatic cell hybridization experiments between tumorigenic and nontumorigenic cells indicate that the differentiated state of the cells carrying the activated oncogene is important in the regulation of their expression.

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References

  1. ar-RushdiA., NishikuraK., EriksonJ., WattR., RoveraG. and CroceC.M. (1983): Differential expression of the translocated and of the untranslocated c-myc gene in Burkitt lymphoma. - Science 222, 390–393.

    Google Scholar 

  2. AvilesD., JamiJ., RoussetJ.P. and RitzE. (1977): Tumor x host cell hybrids in the mouse: chromosomes from the normal cell parent maintained in malignant hybrid tumors. - J. National Cancer Institute 58, 1391–1399.

    Google Scholar 

  3. BregulaV., KleinG. and HarrisH. (1971): The analysis of malignancy by cell fusion. III Hybrids between diploid fibroblasts and other tumour cells. - J. Cell Science 8, 681–692.

    Google Scholar 

  4. ColbyW., CheneE., SmithD. and LevinsonA. (1983): Identification and nucleotide sequence of a human locus homologous to the v-myc oncogene of avian myelocytomatosis virus MC29. - Nature 301, 722–725.

    Google Scholar 

  5. CroceC.M., GirardiA.J. and KoprowskiH. (1973): Assignment of the T-antigen gene of simian virus 40 to human chromosome C-7. - Proc. Natl. Acad. Sci. USA 70, 3617–3620.

    Google Scholar 

  6. CroceC.M. and KoprowskiH. (1974): Concordant segregation of the expression of SV40 T-antigen and human chromosome 7 in mouse human hybrid subclones. - J. Exp. Med. 139, 1350–1353.

    Google Scholar 

  7. CroceC.M. and KoprowskiH. (1974): Somatic cell hybrids between peritoneal mouse macrophages and SV40-transformed human cells. I. Positive control of the transformed phenotype by the human chromosome 7 carrying the SV40 genome.- J. Exp. Med. 140, 1221–1229.

    Google Scholar 

  8. CroceC.M. and KoprowskiH. (1975): Assignment of gene(s) for cell transformation to human chromosome 7 carrying the SV40 genome. - Proc. Natl. Acad. Sci. USA 72, 1658–1660.

    Google Scholar 

  9. CroceC.M., AdenD. and KoprowskiH. (1975): Somatic cell hybrids between mouse peritoneal macrophages and SV40 transformed human cell. II: Presence of the human chromosome 7 carrying the SV40 genome in the cells of tumors induced by the hybrid cells. - Proc. Natl. Acad. Sci. USA 72, 1397–1400.

    Google Scholar 

  10. CroceC.M., AdenD. and KoprowskiH. (1975): Tumorigenicity of mouse-human diploid hybrids in nude mice. - Science 190, 1200–1202.

    Google Scholar 

  11. CroceC.M. (1977): Assignment of the integration site for Simian virus 40 to chromosome 17 in GM54VA, a human cell line transformed by Simian virus 40. - Proc. Natl. Acad. Sci. USA 74, 315–318.

    Google Scholar 

  12. CroceC.M., ShanderM., MartinisJ., CicurelL., D'AnconaG.G., DolbyT.W. and KoprowskiH. (1979): Chromosomal location of the human immunoglobulin heavy chain genes. - Proc. Natl. Acad. Sci. USA 76, 3416–3419.

    Google Scholar 

  13. CroceC.M., ThierfelderW., EriksonJ., NishikuraK., FinanJ., LenoirG. and NowellP.C. (1983): Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C locus in Burkitt lymphoma. - Proc. Natl. Acad. Sci. USA 80, 6922–6926.

    Google Scholar 

  14. CroceC.M., EriksonJ., ar-RushdiA., AdenD., NishikuraK. (1984): The translocated c-myc oncogene of Burkitt lymphoma is transcribed in plasma cells and repressed in lymphoblastoid cells. - Proc. Natl. Acad. Sci. USA 81, 3170–3174.

    Google Scholar 

  15. Dalla FaveraR., BregniM., EriksonJ., PattersonD., GalloR.C. and CroceC.M. (1982): Human c-myc onc-gene is located in the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc. Natl. Acad. Sci. USA 79, 7824–7827.

    Google Scholar 

  16. DefendiV., EphrussiB., KoprowskiH. and ToshihidaM.C. (1967): Properties of hybrids between polyoma-transformed and normal mouse cells. -Proc. Natl. Acad. Sci. USA 57, 299–305.

    Google Scholar 

  17. EmanuelB.S., SeldenJ.R., ChagantiR.S.K., JhanwarS., NowellP.C. and CroceC.M. (1984): The 2p breakpoint of a 2;8 translocation in Burkitt lymphoma interrupts the V locus. - Proc. Natl. Acad. Sci. USA 81, 2444–2446.

    Google Scholar 

  18. EriksonJ., MartinisJ. and CroceC.M. (1981): Assignment of the human genes for immunoglobulin chains to chromosome 22. - Nature 294, 173–175.

    Google Scholar 

  19. EriksonJ., NishikuraK., ar-RushdiA., FinanJ., EmanuelB., LenoirG., NowellP.C. and CroceC.M. (1983): Translocation of an immunoglobulin locus to a region 3′ of an unrearranged c-myc oncogene enhances c-myc transcription. - Proc. Natl. Acad. Sci. USA 80, 7581–7585.

    Google Scholar 

  20. EriksonJ., ar-RushdiA., DrwingaH.L., NowellP.C. and CroceC.M. (1983): Transcriptional activation of the c-myc oncogene in Burkitt lymphoma. Proc. Natl. Acad. Sci. USA 80, 820–324.

    Google Scholar 

  21. HarrisH., MillerO.J., KleinG., WorstP. and TachibanaT. (1969): Suppression of malignancy by cell fusion. - Nature 223, 363–368.

    Google Scholar 

  22. HaywardW.S., NeelB.G., AstrinS.M. (1981): Activation of a cellular one gene by promoter insertion in ALV-induced lymphoid leukosis. - Nature 290, 475–480.

    CAS  PubMed  Google Scholar 

  23. JonassonJ., PoveyS. and HarrisH. (1977): The analysis of malignancy by cell fusion — VII. Cytogenetic analysis of hybrids between malignant and diploid cells of tumors derived from them.- J. Cell Science 24, 217–254.

    Google Scholar 

  24. KleinG. (1981): The role of gene dosage and genetic transposition in carcinogenesis. - Nature 294, 313–318.

    Google Scholar 

  25. KoprowskiH. and CroceC.M. (1977): Tumorigenicity of simian virus 40 transformed human cells and mouse-human hybrids in nude mice. -Proc. Natl. Acad. Sci. USA 74, 1141–1146.

    Google Scholar 

  26. LenoirG.M., Preud'HommeJ.L., BernheimA. and BergerR. (1982): Correlation between immunoglobulin light chain expression and variant translocation in Burkitt's lymphoma. - Nature 298, 474–476.

    Google Scholar 

  27. ManolovG. and ManolovaY. (1971): Marker band in one chromosome 14 from Burkitt lymphoma. Nature 237, 33–34.

    Google Scholar 

  28. NishikuraK., ar-RushdiA., AriksonJ., WattR., RoveraG. and CroceC.M. (1983): Differential expression of the normal and of the translocated human c-myc oncogenes in B cells. - Proc. Natl. Acad. Sci. USA 80, 4822–4826.

    Google Scholar 

  29. NishikuraK., ar-RhsudiA., EriksonJ., DeJesusE., DuganD. and CroceC.M. (1984): Repression of rearranged μ gene and translocated c-myc in mouse 3T3 cells × Burkitt lymphoma cell hybrids. - Science 224, 399–402.

    Google Scholar 

  30. NowellP.C. and HungerfordD.A. (1960): A minute chromosome in chronic granulocytic leukemia. - Science 132, 1497.

    Google Scholar 

  31. RowleyJ.D. (1973): A new consistent chromosomal abnormality in chronic myclogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. - Nature 243, 290–293.

    Google Scholar 

  32. RowleyJ.D. (1983): Identification of the constant chromosome regions involved in human, hematologic malignant disease. - Science 216, 749–751.

    Google Scholar 

  33. ScarlettaL.J. and EphrussiB. (1965): Hybridization of normal. and neoplastic cells in vitro. - Nature 205, 1169–171.

    Google Scholar 

  34. StanbridgeE.J. and WilkinsonA. (1978): Analysis of malignancy in human cells: malignant and transformed phenotypes are under separate genetic control. - Proc. Natl. Acad. Sci. USA 75, 1466–1469.

    Google Scholar 

  35. WattR., StantonL.W., MarcuK.B., GalloR.C., CroceC.M. and RoveraG. (1983): Nucleotide sequence of cloned cDNA of the human c-myc gene. -Nature 303, 725–728.

    Google Scholar 

  36. WattR., NishikuraK., SorrentinoJ., ar-RushdiA., CroceC.M. and RoveraG. (1983): The structure and nucleotide sequence of the 5′ end of the human c-myc gene. - Proc. Natl. Acad. Sci. USA 80, 6307–6311.

    Google Scholar 

  37. WienerF., KleinG. and HarrisH. (1974): The analysis of malignancy by cell fusion. III Hybrids between diploid fibroblasts and other tumour cells. - J. Cell Science 16, 189–198.

    Google Scholar 

  38. YunisJ. (1983): The chromosomal basis of human neoplasia. - Science 221, 227–240.

    Google Scholar 

  39. ZechL., HaglundV., NilssonN., KleinG. (1976): Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas. - International Journal of Cancer 17, 47–56.

    Google Scholar 

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  1. The Wistar Institute of Anatomy and Biology, 36th at Spruce Street, 19104, Philadelphia, PA, USA

    C. M. Croce

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  1. C. M. Croce
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Croce, C.M. Genetics of B-cell neoplasia. Eur J Epidemiol 1, 11–18 (1985). https://doi.org/10.1007/BF00162307

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