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A redefinition of the Asp-Asp domain of reverse transcriptases

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Summary

The rules defining the Asp-Asp domain of RNA-dependent polymerases deduced by Argos (1988) were tested in a set of 53 putative reverse transcriptases (RTs) sequences. Since it was found that some of these rules are not followed by RTs coded by bacteria, group 11 introns, and non-LTR retrotransposons, we present here a more strict definition of the Asp-Asp domain.

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Abbreviations

RT:

reverse transcriptase

DD:

Asp-Asp

ORF:

open reading frame

mt:

mitochondria

pt:

plastid

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Authors and Affiliations

  1. Departamento de Biología, Facultad de Ciencias, UNAM, Cd. Universitaria, Apartado Postal 70-407, 04511, México, D.F. Mexico

    A. M. Velasco, L. Medrano & A. Lazcano

  2. Department of Biochemical and Biophysical Sciences, University of Houston, 77204-5500, Houston, TX, USA

    J. Oró

Authors
  1. A. M. Velasco
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  2. L. Medrano
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  3. A. Lazcano
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  4. J. Oró
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Velasco, A.M., Medrano, L., Lazcano, A. et al. A redefinition of the Asp-Asp domain of reverse transcriptases. J Mol Evol 35, 551–556 (1992). https://doi.org/10.1007/BF00160216

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  • DOI: https://doi.org/10.1007/BF00160216

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