Abstract
A combined vaccine against measles (Edmonston-Zagreb 19 strain), mumps (Rubini strain) and rubella (Wistar RA 27/3 strain) was administered to a group of 46 children aged 10–12 months simultaneously with booster doses of compulsory diphtheria-tetanus toxoid and oral poliovirus vaccine. A second group of 53 children aged 15–24 months who had received booster doses of the compulsory vaccines 5 to 12 months before was also vaccinated.
The same seroconversion rates (100%) and similar antibody titers for rubella were observed in both groups. The same seroconversion rates for mumps (93%) and similar rates for measles (98 and 94%) were observed in the two groups.
Significantly lower antibody titers for measles and mumps were found in the first group, but they were compensated by an earlier protection, a reduction of number of visits for immunization, costs for the community, and improvement in parental compliance.
These results confirm that Edmonston-Zagreb 19 and Rubini strains are still immunogenic even when they are combined with Wistar RA 27/3 strain. Moreover, a long term follow-up in order to verify the persistence of protective antibody levels in both groups of children, could suggest that combined measles, mumps and rubella vaccine could be given earlier (at 10–12 months of age), simultaneously with booster doses of diphtheria and tetanus toxoid and of trivalent oral poliovirus vaccine.
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References
AlbrechtP., EnnisF.A., SaltzmanE.J.et al. (1977): Persistence of maternal antibody in infants beyond 12 months: mechanism of measles vaccine failure - J. Pediatr. 91: 715–718.
BrunelP.A., NovelliV.M., LiptonS.V., PollockB. (1988): Combined vaccine against measles, mumps, rubella and varicella - Pediatrics 81: 779–784.
GarenneM., Leroy0., BeauJ.et al. (1991): Child mortality after high-titre measles vaccine. Prospective study in Senegal - Lancet, II: 903–907.
GlückR., HoskinsJ.M., WegmannA.et al. (1986): Rubini, a new live attenuated mumps vaccine virus strain for human diploid cells - Develop. Biol. Standard 65: 29–35.
HalseyN.A., MannG., ModeF.et al. (1985): Response to measles vaccine in Haitian infants 6 to 12 months old: influence of maternal antibodies, malnutrition, and concurrent illness - N. Engl. J. Med. 313: 544–549.
IkicD.M. (1983): Edmonston-Zagreb strain of measles vaccine: Epidemiologic evaluation in Yugoslavia - Rev. Inf. Dis. 5: 558–563.
JustM., BergerR., GlückR. and WegmannA. (1985): Feldversuch mit einer neuartigen human diploidzellvakzine (HDCV) gegen masern, mumps, und röteln - Schweiz. Med. Wschr. 115: 1727–1730.
KhanumS., UddinN., GarelickH.et al. (1987): Comparison of Edmonston-Zagreb and Schwarz strain of measles vaccine given by aerosol or subcutaneous injection - Lancet, II: 150–153.
KrugmanR.D., RosenbergR., McIntoshK.et al. (1977): Further attenuated measles vaccines: the need for revised recommendations - J. Pediatr. 91: 766–767.
MarksJ.S., HaydenG.F. and OrensteinW.A. (1982): Methodologic issues in the evaluation of vaccine effectiveness: Measles vaccines at 12 vs 15 months -Am. J. Epidemiol. 116: 510–523.
ReubenF.L., SmithE.A., FosterS.O.et al. (1973): Simultaneous administration of smallpox, measles, yellow fever and diphtheria-pertussis-tetanus antigens to Nigerian children - Bull. WHO 48: 175–181.
SabinA.B., ArechigaA.F. and ValdespinoJ. (1984): Succesful immunization of infants with and without maternal antibody by aerosol measles vaccine. II. Vaccine comparison and evidence for multiple antibody response - JAMA 251: 2363–2371.
SherrodJ.L., KaneR., CherryJ.et al. (1983): Effect of timing of measles vaccination on compliance with immunizations during the second year of live -Pediatrics 102: 186–190.
SimoesE.A.F., BalrayV., SelvakumarR. and Jacob JohnT. (1988): Antibody response of children to measles vaccine mixed with diphtheria-pertussis tetanus or diphtheria-pertussis-tetanus-poliomyelitis vaccine - Am. J. Dis. Child. 142: 309–311.
TidjaniO., GuerinN., LecamN.et al. (1989): Serological effects of Edmonston-Zagreb, Schwarz and AIK-C measles vaccine strains given at ages 4–5 or 8–10 months, Lancet, II: 1357–1360.
ThomsonM.K. (1988): Needing doubts about where to vaccinate - Br. Med. J. 297: 779–780.
WhiteCC, KoplanJ.P. and OrensteinW.A. (1985): Benefits, risks and costs of immunization for measles, mumps and rubella - Am. J. Publ. Health. 75: 739–744.
WhittleH.C., RowlandM.G.M., MannG.F.et al. (1984): Immunization of 4–6 month old Gambian infants with Edmonston-Zagreb measles vaccine - Lancet, II: 834–837.
WhittleH.C., MannG., EcclesM.et al. (1988): Effects of dose and strain of vaccine on success of measles vaccination of infants aged 4–5 months - Lancet, II: 963–966.
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Giammanco, G., Li Volti, S., Salemi, I. et al. Immune response to simultaneous administration of a combined measles, mumps and rubella vaccine with booster doses of diphtheria-tetanus and poliovirus vaccine. Eur J Epidemiol 9, 199–202 (1993). https://doi.org/10.1007/BF00158792
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DOI: https://doi.org/10.1007/BF00158792